This paper uses a disaggregated approach to study the volatility of common stocks at the market, industry, and firm levels. Over the period from 1962 to 1997 there has been a noticeable increase in firm-level volatility relative to market volatility. Accordingly, correlations among individual stocks and the explanatory power of the market model for a typical stock have declined, whereas the num...

DURING the last two years of the Great War your president and I had to make our way to work every day through wards crowded with wounded men, the great majority of them suffering from a streptococcus infection of their wounds. And in 1918 in those same wards we saw dozens of men die from the deadly streptococcus pneumonia that so frequently followed influenza dutring the epidemic. The end of th...

W ith the recent death of E J M (Moran) Campbell, respiratory medicine lost one of its most notable figures of the last 50 years. Moran Campbell graduated in medicine from the Middlesex Hospital London in 1949 following a career defining intercalated BSc in physiology. He then worked as a researcher and clinician at the Middlesex and later at the Royal Postgraduate Medical School and Hammersmit...

Despite extensive investigation, many features of prion protein misfolding remain enigmatic. Physicochemical variables known to influence misfolding are reviewed to help elucidate the mechanism of prionogenesis and identify salient features of PrP(Sc), the misfolded conformer of the prion protein. Prospective work on refinement of candidate PrP(Sc) models based on thermodynamic considerations w...

OBJECTIVES Determining the minimal clinically important difference (MCID) of questionnaires on an interval scale, the trait level (TL) scale, using item response theory (IRT) models could overcome its association with baseline severity. The aim of this study was to compare the sensitivity (Se), specificity (Sp), and predictive values (PVs) of the MCID determined on the score scale (MCID-Sc) or ...

Primary culture of human Schwann cells (SCs) and vestibular schwannoma (VS) cells are invaluable tools to investigate SC physiology and VS pathobiology, and to devise effective pharmacotherapies against VS, which are sorely needed. However, existing culture protocols, in aiming to create robust, pure cultures, employ methods that can lead to loss of biological characteristics of the original ce...

With the ubiquitous availability of parallel architectures, the burden falls on programmers’ shoulders to write correct parallel programs that have high performance and portability across different systems. One of the major issues that complicates this task is the intricacies involved with the underlying memory consistency models. Sequential Consistency (SC) is the simplest and most intuitive m...

In this article, manufacturer-retailer supply chain coordination (SCC) has been developed under periodic review inventory system. In the studied model, the retailer as downstream member uses periodic review inventory policy and decides about review period (T) and order-up-to-level (R). Also, the manufacturer as upstream member faces EPQ system and determines the number of shipments from manufac...

Psychotic fear and anxiety disturbances are seen at a relatively high frequency in patients with schizophrenia. Atypical anti-psychotics are believed to show superior efficacy in reducing these symptoms. However, clinical and preclinical evidence regarding their anxiolytic efficacy has been mixed. In this study, we evaluated the possible anxiolytic property of two atypicals clozapine and olanza...