Forty-five cases of systemic neonatal candidiasis were diagnosed over a 9-year period in a neonatal intensive care unit; 42 infants weighted less than 1.5 kg. All had been very ill with preceding bacterial sepsis and other complications of low birthweight. Where treatment was instituted the mortality was low (4 out of 39 dying) and complications of treatment were transitory. We therefore recomm...

Ocular complications are among the most common cause of discomfort and disability in patients with cystinosis, affecting virtually all individuals with nephropathic cystinosis if left untreated. Photophobia results from accumulation of cystine crystals within the corneal tissue. Compliance with recommended therapy can reverse this change, resulting in resolution of symptoms. Other ocular struct...

Acute intermittent porphyria (AIP) is an autosomal dominant genetic defect in heme synthesis. Patients with this illness can have episodic life-threatening attacks characterized by abdominal pain, neurological deficits, and psychiatric symptoms. Feigning this illness has not been reported in the English language literature to date. Here, we report on a patient who presented to the hospital with...

In developing countries, diligent efforts have been devised to screen and monitor the patients closely and have helped preventing morbidity and mortality due to iron overload. However, infection-related deaths in developing and developed countries still occur [2]. Invasive fungal infections are the major cause of infections in patients with thalassemias. This high mortality rate stems, in part,...

gCube is a new service-oriented application framework that supports the on-demand sharing of resources for computation, content and application services. gCube enables the realization of e-infrastructures that support the notion of Virtual Research Environments (VREs), ie collaborative digital environments through which scientists, addressing common research challenges, exchange information and...

Deriving gradient algorithms for time-dependent neural network structures typically requires numerous chain rule expansions, diligent bookkeeping, and careful manipulation of terms. We show, however, that an eecient gradient descent algorithm may be formulated for any network structure with virtually no eeort using a set of simple block diagram manipulation rules. Examples are provided that ill...

The cervical lymph nodes (LNs), along with being the primary site of lymphomas, are also the draining sites for malignancies of the gastrointestinal tract, breasts, lungs, etc. Hodgkin’s disease also most commonly affects the cervical and axillary LNs. We, in the era of modern techniques for diagnosing malignancies, stress the fact that a diligent histopathological examination of the background...

A new failure mechanism has been discovered for today’s latest high volumetric efficiency multilayer chip capacitors. Over the past couple of years, the drive for lower costs has been promoted by the replacement of silver palladium electrodes by nickel. Diligent qualification procedures predicted very long life. However, experience has uncovered an Achilles heel. The capacitors fail when expose...

Many factors have been identified as essential to, or at least associated with, creative people and the creative process – from divine inspiration to diligent perspiration. Work in psychology and some AI programs suggest useful characteristics of creative ideas and mechanisms that are likely components of a model of creativity. An essential part of the model presented here is the ability to rea...