A patient with renal failure developed widespread calcification in the thighs after the injection of iron-dextran (Imferon). This is considered as an example of calciphylaxis, a process in which calcium is laid down in parts of the body following the administration of a "challenger." Iron-dextran is a known challenger, and should be used with caution in uraemic subjects, who may be sensitized b...

Calciphylaxis presenting as progressive painful necrosis of the skin and subcutaneous tissue in patients of chronic renal failure is increasingly recognized owing to the greater awareness of the condition w1–11x. Pathogenesis remains uncertain and specific therapy is debatable. We report a case with facial involvement, which to our knowledge has not been documented before. This patient subseque...

A patient with secondary hyperparathyroidism due to chronic renal failure developed epidermal and follicular calcification without concomitant dermal calcification in the lesions of toxic epidermal necrolysis. We propose that the combination of keratinocyte necrosis and an elevated serum calcium-phosphorus product resulted in epidermal calciphylaxis.

*Corresponding author: Jeong Hee Cho-Vega, MD, PhD, Department of Pathology, Dermatopathology Division, Miami, USA, Email: [email protected] A 44-year-old Hispanic man presented with painful feet and penis. The past medical history was notable for end-stage renal disease, type 2 diabetes mellitus, hypertension, and peripheral vascular disease. The patient was on peritoneal dialysis. Medicati...