Cardiovascular calcification is a growing burden and a leading predictor of and contributor to acute cardiovascular events. Arterial calcification associates with a 4-fold increase in cardiovascular events, and patients with aortic valve calcification have a 5-year event-free survival rate of only 26%,1,2 worse than that of many cancers. Despite massive healthcare costs and extensive research e...

OBJECTIVE Vascular calcification which refers to ectopic mineralization in vascular cells is associated with several conditions, such as chronic kidney disease, atherosclerosis, and diabetes mellitus. Estrogen-related receptor (ERR)γ is a member of the orphan nuclear receptor superfamily, which plays diverse roles in regulating homeostatic and metabolic processes. However, the role of ERRγ in v...

BACKGROUND Atherosclerosis in different vessel beds shares lifestyle and environmental risk factors. It is unclear whether this holds for genetic risk factors. Hence, for the current study genetic loci for coronary artery calcification and serum lipid levels, one of the strongest risk factors for atherosclerosis, were used to assess their relation with atherosclerosis in different vessel beds. ...

Calcification is a common cause of failure of natural and bioprosthetic valves (BPV). Prior research on patients with chronic kidney disease identified increased calcium-phosphorus (Ca-P) product as a risk factor for both arterial and valvular calcifications, an aspect not thoroughly investigated in general population. The aims of our study were to analyse the functional impact of native and bi...

Vascular calcification in patients with chronic kidney disease was mentioned for the first time in the 19 century when Virchow described the appearance of metastatic calcification in patients with kidney failure. The subject has gained great interest in recent years as many studies described that a high percentage of patients on chronic haemodialysis show vascular calcification, the extent of w...

Iglesias-Prieto et al. (1) present 24 h of continuous temperature, conductivity, and sealevel data recorded at a submarine spring in Mexico and argue that Crook et al. (2) attribute changes in coral calcification only to changes in aragonite saturation (Ωarag) while ignoring these other parameters and their variability. On the contrary, Crook et al. (2, 3) conducted extensive monitoring of all ...

Background: The aim of study was to evaluate the impact plaque calcification on symptoms patients with Peyronie’s disease (PD) and mental health in PD or without calcification. Methods: We performed a retrospective analysis clinical database single andrology clinic. extracted 551 patients, we sorted them into two groups: first group included 201 calcification; second 350 inclusion criteria for ...

The purpose of this paper is to compare the value offluoroscopy and tomography in distinguishing aortic from mitral valve calcification. In view of this difficulty, certain criteria are recorded to aid their identification. Aortic valve calcification was first described in 1672 by Rayger (quoted by Bonetus, 1679). Eighty-two years later, Morgagni recorded a patient dying in cardiac failure who ...

INTRODUCTION Soft tissue calcification, including both dystrophic calcification and heterotopic ossification, may occur following injury. These lesions have variable fates as they are either resorbed or persist. Persistent soft tissue calcification may result in chronic inflammation and/or loss of function of that soft tissue. The molecular mechanisms that result in the development and maturati...

The basal ganglia from 33 patients (all over one year of age) with Down's syndrome were examined pathologically. Forty-five per cent had calcification. Basal ganglia calcification was localised to a constant area of globus pallidus and became more prominent with increased age. Calcification and amyloid degeneration of the adjacent blood vessels were present. The proximity of abnormal blood vess...