Blood spots taken by finger prick collected on filter paper cards can provide an option to venous blood extraction in monitoring 17-OHP levels in children with Congenital Adrenal Hyperplasia (CAH). This study was done to evaluate the usefulness of blood spot 17-OHP in monitoring disease control in pre-pubertal children with CAH, to correlate it with simultaneously extracted venous 17-OHP levels...

OBJECTIVE To analyze the mutational spectrum of steroid 21-hydroxylase (CYP21) and the genotype- phenotype correlation in patients with congenital adrenal hyperplasia (CAH) registered in the Middle European Society for Pediatric Endocrinology CAH database, and to design a reliable and rational approach for CYP21 mutation detection in Middle European populations. DESIGN AND METHODS Molecular a...

OBJECTIVE Very little is known about the mental health status in children with genetic causes of hyperandrogenism. This study sought to characterize psychiatric morbidity in this group. DESIGN/METHODS Children (8-18 years) with the diagnosis of classic congenital adrenal hyperplasia (CAH) or familial male precocious puberty (FMPP) underwent a semi-structured psychiatric interview, the Kiddie ...

A comprehensive, validated psychosocial education program (PEP) titled “The CAH Family Workshop” was developed a decade ago to meet the needs of families with Congenital Adrenal Hyperplasia (CAH). Engaging professionals experienced in the field of endocrinology, together with information from parent interviews, was key to development of the program’s content. Validation of the program was condu...

Capillary adhesion is so remarkable in micro–nano technology that it can seriously influence accuracy and safety. The shapes optimized by dissolution provide a method to weaken or even eliminate capillary adhesion. Based on the experiments of soluble fibers, this work demonstrates process an optimization force, unique geometrical sculpted effectively mechanism elimination relevant stability men...

Background Dysfunction in the hypothalamic-pituitary-adrenal axis has been associated with depressive and anxiety disorders. Little is known about risk for these disorders among individuals congenital adrenal hyperplasia (CAH), a form of primary insufficiency. Objective We investigated prevalence antidepressant prescriptions two large healthcare databases insured children, adolescents, young ad...

Cyanuric acid hydrolase (CAH) catalyzes the hydrolytic ring-opening of cyanuric acid (2,4,6-trihydroxy-1,3,5-triazine), an intermediate in s-triazine bacterial degradation and a by-product from disinfection with trichloroisocyanuric acid. In the present study, an X-ray crystal structure of the CAH-barbituric acid inhibitor complex from Azorhizobium caulinodans ORS 571 has been determined at 2.7...

The development of community animal health (CAH) is an invaluable tool for addressing a series of challenges, particularly for the policy-maker, whose prime concern is public welfare. This paper examines three of the major challenges which confront governments, particularly the governments of less-developed countries, namely, the collapse of government services, the crucial issue of poverty red...

OBJECTIVE Evaluate the Neonatal Screening Program (NSP) for congenital adrenal hyperplasia (CAH) of the Department of Health of the State of Santa Catarina (Secretaria de Estado da Saúde de Santa Catarina, SES/SC), and provide information to improve the program. SUBJECTS AND METHODS Descriptive, retrospective study of 748,395 children screened between January 2001 and December 2010. We analyz...