Background: Polybrominated Biphenyls (PBBs) and Polybrominated Diphenyl Ethers (PBDEs) are semi-permanent Halogenated compounds that are mainly used in flame retardant. These contaminants as endocrinedisrupting associated with dysfunction of immune, endocrine and nervous systems. Influence various physiological processes such as menarche, birth weight, fetus growth and development, head circumf...