Oral doses of caffeine increase the urinary excretion of calcium, magnesium, sodium and chloride for at least 3 h after consumption. The hypercalciuric effect can be blocked by adenosine receptor agonists. The effect is proportional to dose per lean body mass and no adaptation to the urinary losses occurs with continuing consumption of caffeine. Uncompensated losses of calcium would be a risk f...

BACKGROUND Binge co-consumption of highly caffeinated energy drinks with alcohol (ethanol [EtOH]) has become a common practice among adolescents/young adults and has been associated with an increased incidence of hazardous behaviors. Animal models are critical in advancing our understanding the neurobehavioral consequences of this form of binge drinking. Surprisingly, virtually no work has expl...

the influence of aluminum on some serum parameters related to bone metabolism has been investigated by daily administration of aluminum over different periods of time. daily administration of aluminum (1 mg/kg bw) for 20 or 50 days elevated serum phosphorous concentration by 16 percent and had no significant effect on serum calcium level. when aluminum was injected as a complex with citric acid...

In 1937, SASLOW1) reported that the oxygen consumption of the skeletal muscle was increased by subcontracture dose of caffeine. AXELSON2) observed the mechanical change of skeletal muscle induced by caffeine and pointed out the fact that caffeine was a useful agent for the analysis of excitation-contraction coupling mechanism. He found that caffeine was also able to induce the contracture in th...

AIMS The relationship between caffeine consumption and the occurrence of arrhythmias remains controversial. Despite this lack of scientific evidence, counselling to reduce caffeine consumption is still widely advised in clinical practice. We conducted a systematical review and meta-analysis of interventional studies of the caffeine effects on ventricular arrhythmias. METHODS AND RESULTS The s...

BACKGROUND There has been some speculation that caffeine consumption may affect breast cancer. Most case-control studies have not documented evidence of a caffeine-breast cancer incidence link; however, there has been very little analysis of the possible effects of caffeine consumption on breast cancer survival. METHODS We examined overall a 20-year survival of 96 women treated for breast can...

BACKGROUND A variant (rs1495741) in the gene for the N-acetyltransferase 2 (NAT2) protein is associated with skin intrinsic fluorescence (SIF), a noninvasive measure of advanced glycation end products and other fluorophores in the skin. Because NAT2 is involved in caffeine metabolism, we aimed to determine whether caffeine consumption is associated with SIF and whether rs1495741 is associated w...