FOXP3 is playing an essential role for T regulatory cells and is involved in the molecular mechanisms controlling immune tolerance. Although the biological relevance of this transcription factor is well documented, the pathways responsible for its induction are still unclear. The current study reveals structure and function of the human FOXP3 promoter, revealing essential molecular mechanisms o...

The gene encoding protein zero (P0), the most abundant protein of peripheral nervous system myelin, is expressed uniquely in Schwann cells. Previous studies have demonstrated that much of the cell type specificity of this expression is due to transcriptional control elements in the 1.1-kilobase pair 5'-regulatory region of the gene. We have now analyzed this region and have identified a set of ...

To detect genetic variations among different Simmondsia chinensis genotypes, two gene targeted markers, start codon targeted (SCoT) polymorphism and CAAT box-derived polymorphism (CBDP) were employed in terms of their informativeness and efficiency in analyzing genetic relationships among different genotypes. A total of 15 SCoT and 17 CBDP primers detected genetic polymorphism among 39 Jojoba g...

to some authors, eASs are supposed to challenge the canonical paradigms of toxicology, e.g., linear versus non-monotonic dose response, low dose effects versus threshold concept. An overview of the symposium is given here; authorized presentations and the abstract book are available on the websites of the three organizing institutes, i.e., ISS (http://www.iss.it/inte/ prog/cont.php?id=263&lang=...

objectives : optimum viewing conditions facilitate identification of radiographic details and decrease the need for retakes, patients’ costs and radiation dose. this study sought to evaluate the effects of different viewing conditions on radiographic interpretation. materials and methods: this diagnostic study was performed by evaluating radiograph of a 7mm-thick aluminum block, in which 10 hol...

Altex 31, 2/14 224 Alternatives Initiative in Sri Lanka: Preand Post-Conference Workshops at the Inaugural Scientific Conference of the Sri Lanka Association for Laboratory Animal Science Mangala Gunatilake 1, Francois Busquet 2, and Mohammad A. Akbarsha 3 Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka; Center for Alternatives to Animal Testing (CAAT)-Europe, Ko...