نتایج جستجو برای: ca2 sensitization
تعداد نتایج: 67416 فیلتر نتایج به سال:
inhalation of fungal spores is shown to participate in the development of allergic rhinitis symptoms. in this study, relation between presence of alternaria in the human nasal cavity and allergic rhinitis is assessed. in a case-control study, 58 allergic rhinitis patients were compared with a well-matched control group of fifty healthy volunteers for sensitization to alternaria (by skin prick t...
Synaptic plasticity in the mesolimbic dopamine (DA) system is critically involved in reward-based conditioning and the development of drug addiction. Ca2+ signals triggered by postsynaptic action potentials (APs) drive the induction of synaptic plasticity in the CNS. However, it is not clear how AP-evoked Ca2+ signals and the resulting synaptic plasticity are altered during in vivo exposure to ...
Although arteriolar contraction is dependent on Ca2+-induced myosin phosphorylation, other mechanisms including Ca2+ sensitization and time-dependent phenomena such as cytoskeletal and cellular reorganization may contribute to contractile events. We hypothesized that if arteriolar smooth muscle exhibits time-dependent behavior this may be manifested in differences in relaxation after short- and...
Transient receptor potential ankyrin 1 (TRPA1) is activated by noxious cold, mechanical stimulation, and irritant chemicals. In our recent study, 9, 10-phenanthrenequinone (9,10-PQ) is the most potent irritant for activation of NRF2 among 1395 cigarette smoke components and it may be, therefore, important to find its additional targets. Here, we show that 9,10-PQ functions as an activator of TR...
Zika virus (ZIKV) has recently caused a worldwide outbreak of infections associated with severe neurological complications, including microcephaly in infants born from infected mothers. ZIKV exhibits high neurotropism and promotes neuroinflammation and neuronal cell death. We have recently demonstrated that N-methyl-d-aspartate receptor (NMDAR) blockade by memantine prevents ZIKV-induced neuron...
value of FeNO, which was defined as the value of 95% in distribution curve, was same or less than 34 ppb. In a univariate analysis, FeNO levels were not associated with age, BMI and smoking history. However, atopy status (18.2 6 11.8 for atopy and 15.16 8.5 for nonatopy groups, P 1⁄4 0.008) and gender (17.8 6 10.2 for male and 14.8 6 9.8 for female groups, P , 0.001) were positively associated ...
We have investigated the mechanism of action of the putative second messenger, cyclic ADP-ribose (cADPR), on the cardiac ryanodine-sensitive Ca(2+)-release channel. Current fluctuations through single Ca(2+)-release channels have been monitored after incorporation into planar phospholipid bilayers. We demonstrate that activation of the channel by cADPR is dependent on activating levels of cytos...
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