Cancer treatment with high LET heavy ion beam, especially, carbon ion beam ((12)C), is becoming very popular over conventional radiotherapy like low LET gamma or X-ray. Combination of Poly(ADP-ribose) polymerase (PARP) inhibitor with xenotoxic drugs or conventional radiation (gamma or X-ray) is the newer approach for cancer therapy. The aim of our study was to compare the radiosensitivity and i...

NAD(P)H:quinone oxidoreductase 1 null (NQO1(-/-)) mice exposed to 3 Gy of gamma-radiation showed an increase in neutrophils, bone marrow hypercellularity, and enlarged lymph nodes and spleen. The spleen showed disrupted follicular structure, loss of red pulp, and granulocyte and megakarocyte invasion. Blood and histologic analysis did not show any sign of infection in mice. These results sugges...

Fos‑related antigen 1 (Fra‑1) has roles in a variety of cell functions, including cell proliferation, differentiation, transformation, and invasiveness, and it is upregulated in various cancers. We investigated the role of Fra‑1 in cellular radioresistance using cells of two human colorectal cancer cell lines, SW620 and SW480. We found that SW620 cells are more sensitive than SW480 cells at dos...

background:  the aim of the study was to estimate the radiation dose during emergency exposure to patients treated with iodine-131 during the isolation period. materials and methods: the dose rate from a sample of 192 patients administrated by three different radioactivity of 131i (3.7, 5.55 and 7.4 gbq) was measured, at 1 meter after 1, 24 and 48 hours post dose administration, at three differ...

background: in order to deliver the precise dose to the target in radiotherapy, absorbed dose to water at the reference point should be assessed. when the calibration procedure is performed for a reference dosimeter in the 60co beam of a secondary standard dosimetry laboratory (ssdl), the total uncertainty in absorbed dose to water (dw) is estimated to be approximately 1.5%. this study attempts...

background: hot lab is a specially designed room in a nuclear medicine hospital where the radiopharmaceuticals are delivered, stored and prepared for dispensing. 99mo/99mtc-generator is the major source in the hot lab used for various medical imaging. it is important to maintain a standard for hot lab procedures to optimize the patient care and minimize radiation exposure to all nuclear medicin...

Yersinia pestis is the causative agent of plague. Although rare, pharyngeal plague in humans has been associated with consumption or handling of meat prepared from infected animals. The risks of contracting plague from consumption of deliberately contaminated food are currently unknown. Gamma radiation is a penetrating form of electromagnetic radiation, and UVC radiation is used for decontamina...

In this study thermosensitive polymeric microspheres obtained in former research were evaluated in vitro for their photoprotective activity. The UVA/UVB ratio was assessed at so called shelf temperature, i.e., at 25 degrees C, and at elevated temperature of 45 degrees C. The evaluated polymers absorb higher levels of UV radiation, when heated from 25 degrees C to 45 degrees C. The MS1 polymer m...

Removing plant pathogens with the sun as a free, available, clean, and sustainable source of energy is interesting. However, there no data for disinfecting major pathogenic bacteria such Pseudomonas syringae Clavibacter michiganensis subsp. by solar ultraviolet radiation. To obtain required time killing these at different temperatures, bacterial suspension active growing cells (approximately 10...

A novel nanocomposite consisted of nanomaterials as (CuO:NiO) and carbon (fuel ash) were designed to absorb solar energy. Thin films were made via casting and spin coating of the dopants nanocomposite thin films, containing different concentration ratios of CuO:NiO. These thin films are precipitated on a glass and copper substrates. The optical properties of the doped fuel ash films with na...