Proinsulin C-peptide has been shown to increase muscle blood flow in type 1 diabetic patients. The underlying mechanism is not fully understood. The aim of this study was to evaluate if the vasodilator effect of C-peptide is mediated by nitric oxide (NO). Eleven type 1 diabetic patients were studied two times and randomized to administration of intravenous and intra-arterial infusion of C-pepti...

Corresponding author: Seok Man Son Department of Internal Medicine, Pusan National University School of Medicine, and Diabetes Center and Endocrine Clinic, Pusan National University Yangsan Hospital, 20 Geumo-ro, Mulgeum-eup,Yangsan 626-770, Korea E-mail: [email protected] C-peptide is a small peptide comprised of 31 amino acids, with a short half-life of approximately 30 minutes. It was first ...

Galanin receptors (provisional nomenclature as recommended by NC-IUPHAR [57]) are activated the endogenous peptides galanin and galanin-like peptide. Human is a 30 amino-acid non-amidated peptide [52]; in other species, it 29 amino acids long C-terminally amidated. Amino 1-14 of highly conserved mammals, birds, reptiles, amphibia fish. Shorter species (e.g. human galanin-1-19 [21] porcine galan...

OBJECTIVE Objective: Although serum C-peptide has increasingly received attention as a new and important risk factor for cardiovascular disease (CVD), the potential mechanisms remain unclear. This study aimed to investigate the association between serum C-peptide as a risk factor for CVD and high-density lipoprotein cholesterol (HDL-C) levels. METHODS The present study included 13,185 partici...

C-peptide is the connecting peptide between the A and B chains of insulin in proinsulin. In this paper, we investigate the interaction between C-peptide and phospholipid bicelles, by circular dichroism and nuclear magnetic resonance spectroscopy, and in particular the pH dependence of this interaction. The results demonstrate that C-peptide is largely unstructured independent of pH, but that a ...

Galanin receptors (provisional nomenclature as recommended by NC-IUPHAR [57]) are activated the endogenous peptides galanin and galanin-like peptide. Human is a 30 amino-acid non-amidated peptide [52]; in other species, it 29 amino acids long C-terminally amidated. Amino 1-14 of highly conserved mammals, birds, reptiles, amphibia fish. Shorter species (e.g. human galanin-1-19 [21] porcine galan...

Solid-phase peptide synthesis in the N-to-C direction, opposite to the classical C-to-N direction of peptide synthesis, provides the synthetically versatile C-terminal carboxyl group for further modification into C-terminally modified peptide mimetics. These are of general interest as potential bioactive agents, particularly as protease inhibitors. Elaboration of peptide mimetics on the solid-p...

OBJECTIVE an increased glomerular filtration rate (GFR) has been postulated as a potential mechanism involved in the progression of diabetic nephropathy. Studies suggest that C-peptide exerts a renoprotective effect on diabetes. The peptide decreases hyperfiltration in patients with type 1 diabetes, as well as in diabetic animal models. In this study, we investigated whether C-peptide causes a ...

Proinsulin is converted to equimolar amounts of insulin and connecting peptide (C-peptide) in pancreatic beta cell secretory granules. The fate of C-peptide, which remains soluble in granules while insulin is crystallized, was studied in a rat insulinoma cell line (INS cells). A pulse-chase approach demonstrated that insulin to C-peptide ratios (I/CP) began to rise in INS cells as soon as conve...

The proinsulin connecting peptide, C-peptide, is a cleavage product of insulin synthesis that is co-secreted with insulin by pancreatic beta-cells following glucose stimulation. Recombinant insulin, used in the treatment of diabetes, lacks C-peptide and preclinical and clinical studies suggest that lack of C-peptide may exacerbate diabetes-associated complications. In accordance with this, seve...