elevated expression of the drug efflux transporter abcg2 seems to correlate with multidrug resistance of cancer cells. specific cox-2 inhibitor celecoxib has been shown to enhance the sensitivity of cancer cells to anticancer drugs. to clarify whether abcg2 inhibition is involved in the sensitizing effect of celecoxib, we investigated whether the expression of abcg2 in breast cancer cell lines ...

electrochemical oxidation of iodide has been studied in the presence of 2-thioborbituric acid using cyclic voltammetry and controlled-potential coulometry. the results indicate that, the resulting iodine takes part in halogenations reaction with 2-thiobarbituric acid. in addition, the present data are indicative of the suitability of iodide as a quasi mediator for determination of 2-thiobarbitu...

treatment of bone metastases comprises over 10% of the workload of a radiation-oncology center. bone metastases produce severe pain and immobility, necessitate narcotic use, and reduce the quality of life. a good palliative treatment must be complete, free from side effects and fast; thus we decided to evaluate strontium-89 (89sr) effectivity for palliation of breast and prostate cancer bone me...

The aim of the paper is to find efficient conditions for the unique solvability of the problem u′(t) = `(u)(t) + q(t), u(a) = h(u) + c, where ` : C([a, b];R) → L([a, b];R) and h : C([a, b];R) → R are linear bounded operators, q ∈ L([a, b];R), and c ∈ R.

A r b e i t e r , K., W i e n A u e r , J . A . , Z ü r i c h B o g n e r , H. , G r u b B o l l w a h n , W. , H a n n o v e r B o r y c z k o , Z . , W a r s c h a u B r e m , G . , M ü n c h e n D e e g e n , E., H a n n o v e r D o r n , R, G r u b E i k m e i e r , H. , G i e ß e n G e r b e r , H. , B e r n G r ü n b a u m , E . G . , G i e ß e n G r ü n d e r , H. -D. , G i e ß e n H o f...

bisphenol-a (bpa) is an industrial xenoestrogen used widely in our living environment. recently, several studies suggested that bpa has destructive effects on dna and chromosomes in normal body cells via estrogen receptors (er). therefore, bpa could be considered as an important mediator in many diseases such as cancer. however, there are still many controversial issues which need clarification...

For a Lipschitz $ \mathbb{Z}- $periodic function \phi:\mathbb{R}\to \mathbb{R}^2 such that \mathbb{R}^2\setminus\{\phi(x):x\in\mathbb{R}\} is not connected, an integer b\ge 2 and \lambda\in (c/{b^{\frac12}},1) $, we prove the following for generalized Weierstrass-type W(x) = \sum\limits_{n 0}^{\infty}{{\lambda}^n\phi(b^nx)} $: box dimension of its graph equal to 3+2\log_b\lambda where c constan...