نتایج جستجو برای: buspirone
تعداد نتایج: 563 فیلتر نتایج به سال:
There is growing interest in zebrafish as a model organism in behavioral pharmacology research. Several anxiety behaviors have been characterized in zebrafish, but the effect of anxiolytic drugs on these parameters has been scarcely studied. The purpose of this work was to assess the predictive validity of acute treatment with anxiolytic drugs on behavioral parameters of anxiety. In the first t...
1-(2-Pyrimidinyl)-piperazine (1-PP) is an active metabolite of several psychoactive drugs including buspirone. 1-PP is also the major metabolite in the human circulation and in rat brains following oral administration of buspirone. This study was conducted to identify the enzyme responsible for the metabolic conversion of 1-PP to 5-hydroxy-1-(2-pyrimidinyl)-piperazine (HO-1-PP) in human liver m...
A descending pathway from the bed nucleus of the stria terminalis (BNST) to nuclei within the hypothalamus and brainstem has been implicated in the generation of anxiety.1 Drugs such as the 5-HT1A agonist, buspirone, and specific serotonin reuptake inhibitors (SSRIs), which are used to treat anxiety behaviors, act to modulate serotonin (5-HT) transmission.2 Hence, 5-HT may act as a neuromodulat...
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