Endocrine therapy has been a mainstay of breast cancer treatment for more than 100 years. The first interventions, oophorectomy for premenopausal women and pharmacologic doses of estrogen for postmenopausal women, have been supplanted by targeted therapy, including selective estrogen receptor modulators (SERMs) like tamoxifen, luteinizing hormone-releasing hormone (LHRH) agonists, and aromatase...

Relevance: Globocan reported 4,390 new breast cancer cases and 1,654 deaths from in the Republic of Kazakhstan (RK) 2020. Molecular diagnostics includes determination Hormone Receptor (HR), HER2, Ki-67 status to detect patients
 with HR-positive tumors administer effective treatment.
 Methods: This observational study included a retrospective analysis incidence, molecular diagnostics,...