BACKGROUND Wound healing is widely discussed in the medical literature. This study compared the healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. METHODS Sixteen rats were randomly assigned to one of two groups, each group 8 rats. A deep second-degree burn on the lower back and 3rd degree burn on upper back of each rat were created with a...

Sepsis remains the major cause of death in patients with major burn injuries. In the present investigation we evaluated the interaction between burn injuries of varying severity and preexisting distant infection. We used Gram-negative bacteria (Pseudomonas aeruginosa and Proteus mirabilis) that were genetically engineered to be bioluminescent, which allowed for noninvasive, sequential optical i...

Ninety-seven of 763 patients admitted to a burn center during a 3-year period had histologically confirmed bacterial or fungal burn wound invasion. Nine of these 97 patients survived and 88 died. Burn wound infection was the principal cause of death in 57 patients and was diagnosed perimortem in an additional 31 patients but was not judged to be the primary cause of death. Pseudomonas aeruginos...

INTRODUCTION We present a standardized Pseudomonas aeruginosa (PA) infected burn-wound model in mice for evaluating new antimicrobials and therapy strategies for PA infections and demonstrate the effect of the antibiotic imipenem in this model. METHODS A 6%-8% total body surface area, full-thickness, scald-burn wound was induced in anesthetized mice. Two study groups (PA-infected burn) were c...

HYPOTHESIS Advances in burn treatment including early excision of the wound have increased survival in patients treated at specialized burn centers. We hypothesized that the patients with delayed wound excision and grafting would experience deleterious outcomes. METHODS From 1995 to 1999, 157 children with acute burns covering 40% or more of total body surface area and having more than 10% of...

OBJECTIVE Burn wound progression is a poorly understood process by which certain superficial partial-thickness burns spontaneously advance into deep partial-thickness or full-thickness wounds. Progression of an injury into deeper tissue is an important phenomenon in the treatment of thermal injury due to the fact that burn wound depth may be a significant determinant of morbidity and treatment....

Bacterial flora in burn patients undergoes change over period of time and is dependent upon many factors. Study of burn flora is not only helpful in locating entry of multidrug resistant bacterial strains into the unit's usual flora but also in determining current antibiotic susceptibilities. Since no studies are available from India that have studied sequential emergence of different microorga...

background wound healing is widely discussed in the medical literature. this study compared the healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. methods sixteen rats were randomly assigned to one of two groups, each group 8 rats. a deep second-degree burn on the lower back and 3rd degree burn on upper back of each rat were created with a st...

Objective: To construct a burn model of early and midterm human Foetal Skin (hFS) in vitro, to observe its morphological and histological changes after transplantation, and to examine the expression of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs), and further to analyse their roles in foetal wound healing preliminarily. Methods: hFS harvested from aborted...

The ultimate goal in the management of burn wounds is to obtain physiological closure in the shortest period of time. Traditional burn wound management involves cleansing, debridement and provision of a moist environment to encourage the process of natural healing. Hence, an ideal dressing material has to maintain a moist environment, act as a bacterial barrier, and as a medium for free exchang...