background the cause of death in burn patients after 48 hours of hospitalization has been reported to be bacterial infections. recently, due to the compounds accelerating the healing process and the intense reduction of treatment side effects, medicinal plants are used to cure burn wound infections. this study aims to investigate the medicinal effect of the ethanolic extract of scrophularia str...

BACKGROUND Acute lung injury (ALI) is a major factor determining morbidity following burns and inhalational injury. In experimental models, factors potentially contributing to ALI risk include inhalation of toxins directly causing cell damage; inflammation; and infection. However, few studies have been done in humans. METHODS We carried out a prospective observational study of patients admitt...

We read with great interest the highly educational review by Rowan et al. on wound healing and treatment of burn patients [1]. As discussed in detail by the authors, burn injury is inextricably linked with some states of inflammation. Acute-phase activation of crucial immune processes is imperative for survival and initiation of wound healing, otherwise inflammation may become detrimental when ...

Burn injuries have a tremendous impact on not only the physical health of burn survivor, but also mental and social outcomes individual their support systems. While much effect occurs at point injury, post-injury pain, infection, scarring, inflammatory response metabolic changes all long-term survivor. The goal following article is to explore how examine long term associated with including diso...

Almost 2 million people in the United States suffer from burns annually. A small percentage of these injuries are fatal, but all require some degree of medical attention. Burn injury is associated with anatomic, physiologic, endocrinologic, and immunologic alterations. These problems need to be identified and treated properly to prevent or minimize the extent of the damage. In recent years, adv...

Burns are one of the most common devastating forms of trauma. Burn patients are ideal hosts for opportunistic infections [1]. Thermal injury causes instant coagulative necrosis, which rapidly becomes a favourable niche for bacterial colonisation and proliferation. The eschar provides a devitalised, protein rich environment, which further benefits bacterial proliferation through its exclusion fr...

Staphylococcus aureus is a common pathogen isolated from burn patients that can form biofilms on burn wounds and implanted deep vein catheters, which often leads to refractory infections or even biofilm-related sepsis. As biofilm formation is usually regulated by environmental conditions, we hypothesized that serum composition may be altered after burn injury, potentially affecting the ability ...

Mortality remains one of the most important end-point quality control parameters to evaluate a burn care system. We retrospectively reviewed the characteristics and multiple organ dysfunction syndrome (MODS) patterns of burn deaths in our center from January 2003 to December 2009. The mortality rate during this time period was 2.3%. Fifty-six patients died, including 49 males and 7 females. The...

The mechanism of alcohol-mediated increased infection in burn patients remains unknown. With the use of a rat model of acute alcohol and burn injury, the present study ascertained whether acute alcohol exposure before thermal injury enhances gut bacterial translocation. On day 2 postinjury, we found a severalfold increase in gut bacterial translocation in rats receiving both alcohol and burn in...

Burn wound sepsis is currently the main cause of morbidity and mortality after burn trauma. Infections by notorious pathogens such as Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii impair patient recovery and can even lead to fatality. In this study, we investigated the effect of burn wound exudates (BWEs) on the virulence of those pathogens. BWEs were collected with...