BACKGROUND Previous functional magnetic resonance imaging (fMRI) studies have shown abnormal functional connectivity in regions involved in emotion processing and regulation in pediatric bipolar disorder (PBD). Recent studies indicate, however, that task-dependent neural changes only represent a small fraction of the brain's total activity. How the brain allocates the majority of its resources ...

Polo-like kinase 1 (Plk1) is a promising target for cancer therapy due to its essential role in cell division. In addition to a highly conserved kinase domain, Plk1 also contains a Polo-Box domain (PBD), which is essential for Plk1's subcellular localization and mitotic functions. We adopted a fluorescence polarization assay and identified a new Plk1 PBD inhibitor T521 from a small-molecule com...

Jiao W., Ma Q., Lv X., Shan A., Li Z. (2017): Gene expression and tissue distribution of β-defensins in Chinese Min pigs and Landrace pigs. Czech J. Anim. Sci., 62, 178–183. β-Defensins are a major group of mammalian antimicrobial peptides and play an important role in innate and adaptive immunity due to their antimicrobial, chemotactic, and regulatory activities. In this study, the tissue dist...

Recent shear experiments in well-entangled polymer solutions demonstrated that interfacial wall slip is the only source of shear rate loss and there is no evidence of shear banding in the micron scale gap. In this work, we experimentally elucidate how molecular parameters such as slip length, b, influence shear inhomogeneity of entangled polybutadiene (PBD) solutions during shear in a small gap...

Functional interactions between a mitogen-activated protein kinase (MAPK) and its regulators require specific docking interactions. Here, we investigated the mechanism by which the yeast osmoregulatory Hog1 MAPK specifically interacts with its activator, the MAPK kinase Pbs2, and its major inactivator, the protein phosphatase Ptp2. We found, in the N-terminal noncatalytic region of Pbs2, a spec...

In an aircraft electric power system (EPS), a supervisory control unit must actuate a set of switches to distribute power from generators to loads, while satisfying safety, reliability and real-time performance requirements. To reduce expensive re-design steps in current design methodologies, such a control problem is generally addressed based on minor incremental changes on top of consolidated...

This study aims to identify practices in Classroom Assessment (PBD) that need be applied by teachers Malaysia. The objective of the is classroom assessment teacher teaching. paper form a concept best implementation PBD through analysis documents related PBD. findings this show there indeed develop an module for each subject facilitate schools. because guided with enough material so generation H...

Plackett-Burman design, central composite design and response surface analysis were carried out with the aim of optimizing culture conditions for -mannanase production from Bacillus licheniformis TJ-101. Screening experiments of Plackett-Burman design were firstly employed to evaluate the effects of 16 variables on -mannanase production. The four identified significant variables, i.e. the conce...

Recent advances in the technology of wireless electronic devices have made possible to build ad–hoc Wireless Sensor Networks (WSNs) using inexpensive nodes, consisting of low–power processors, a modest amount ofmemory, and simplewireless transceivers. Over the last years, many novel applications have been envisaged for distributed WSNs in the area of monitoring, communication, and control. Sens...