Burkholderia mallei is a facultative intracellular pathogen that causes severe disease in animals and humans. Recent studies have shown that the cluster 1 type VI secretion system (T6SS-1) expressed by this organism is essential for survival in a hamster model of glanders. To better understand the role of T6SS-1 in the pathogenesis of disease, studies were initiated to examine the interactions ...

Within the scope of "National Ruam Eradication Project" carried out between 2000-2001, Glanders was eradicated in our country. Unfortunately, 81 horses were culled Türkiye December 2019, following detection Epidemic Büyükada. In reported Uşak and Bolu. No human cases have been reported. is at risk for because its geography. Therefore, reliable fastly Burkholderia mallei by PCR a short time will...

1. Cheng AC, Currie BJ. Melioidosis: epidemiology, pathophysiology and management. Clin Microbiol Rev. 2005;18:383– 416. 2. Currie BJ, Jacups SP. Intensity of rainfall and severity of melioidosis, Australia. Emerg Infect Dis. 2003;9:1538–42. 3. Athan E, Allworth AM, Engler C, Bastian I, Cheng CA. Melioidosis in tsunami survivors. Emerg Infect Dis. 2005;11: 1638–9. 4. Currie BJ. Burkholderia pse...

Bioluminescent imaging (BLI) technology is a powerful tool for monitoring infectious disease progression and treatment approaches. BLI is particularly useful for tracking fastidious intracellular pathogens that might be difficult to recover from certain organs. Burkholderia mallei, the causative agent of glanders, is a facultative intracellular pathogen and has been classified by the CDC as a C...

There continues to be a feared scenario of terrorist attacks with aerosolized microorganisms leading to mass infections. Given the added possibility of resistance to current treatments through genetic engineering or natural emergence, identifying effective antibiotics with novel mechanisms of action is critical to counter such an attack. In this study, we determined the minimum inhibitory conce...

Burkholderia pseudomallei is the causative agent of melioidosis, a severe infection endemic to many tropical regions. Lipopolysaccharide (LPS) is recognized as an important virulence factor used by B. pseudomallei Isolates of B. pseudomallei have been shown to express one of four different types of LPS (typical LPS, atypical LPS types B and B2, and rough LPS) and in vitro studies have demonstra...

Large-scale genomics projects are identifying biomarkers to detect human disease. B. pseudomallei and B. mallei are two closely related select agents that cause melioidosis and glanders. Accurate characterization of metagenomic samples is dependent on accurate measurements of genetic variation between isolates with resolution down to strain level. Often single biomarker sensitivity is augmented...