نتایج جستجو برای: bullous mycosis fungoides

تعداد نتایج: 17535  

Journal: :Blood 2011
Michael K Kiessling Patrick A Oberholzer Chandrani Mondal Maria B Karpova Marie C Zipser William M Lin Michael Girardi Laura E Macconaill Sarah M Kehoe Charlie Hatton Lars E French Levi A Garraway Gernot Polier Dorothee Süss Claus-Detlev Klemke Peter H Krammer Karsten Gülow Reinhard Dummer

Cutaneous T-cell lymphomas (CTCLs) are malignancies of skin-homing lymphoid cells, which have so far not been investigated thoroughly for common oncogenic mutations. We screened 90 biopsy specimens from CTCL patients (41 mycosis fungoides, 36 Sézary syndrome, and 13 non-mycosis fungoides/Sézary syndrome CTCL) for somatic mutations using OncoMap technology. We detected oncogenic mutations for th...

2011
Azita Nikoo

Cutaneous Lymphomas (CL) are a distinctive group of lymphomas; they are the second most frequent extra nodal lymphomas. They can be defined as lymphoproliferative skin infiltrates of T-, Bor NKcell lineage which typically occur in and remain confined to the skin without detectable extracutaneous manifestation 1. The Cutaneous T-cell Lymphoma (CTCL) spectrum is composed of Mycosis Fungoides (MF)...

Journal: :AJNR. American journal of neuroradiology 2002
Raquel del Carpio-O'Donovan Carolyn Freeman

Changes in the brainstem were demonstrated with MR imaging in a patient with mycosis fungoides. Previous reports of CNS involvement in this rare disease have not had similar findings.

Journal: :Blood 2010
Maria R Kamstrup Lise Mette Rahbek Gjerdrum Edyta Biskup Britt Thyssing Lauenborg Elisabeth Ralfkiaer Anders Woetmann Niels Ødum Robert Gniadecki

Deregulation of Notch signaling has been linked to the development of T-cell leukemias and several solid malignancies. Yet, it is unknown whether Notch signaling is involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the most common subtypes of cutaneous T-cell lymphoma. By immunohistochemistry of 40 biopsies taken from skin lesions of mycosis fungoides and Sézary syndrome, w...

2011
Brian Poligone Janet Lin Catherine Chung

INTRODUCTION Cutaneous T cell lymphoma (CTCL) encompasses a heterogeneous group of neoplasms of skin-homing T cells, which includes mycosis fungoides, the most common form, and Sézary syndrome, the leukemia equivalent of mycosis fungoides. Histone deacetylase inhibitors are currently under investigation for their therapeutic value in a variety of conditions. Through multiple mechanisms, they in...

2018
Min Soo Jang Ji Yun Jang Jong Bin Park Dong Young Kang Jin Woo Lee Taek Geun Lee Hyun Hwangbo Kee Suck Suh

Background Folliculotropic mycosis fungoides (FMF) is a variant of mycosis fungoides (MF) that is characterized clinically by variable types of skin eruptions, including plaques, acneiform lesions, and alopecic patches. Histopathologically, FMF is characterized by folliculotropic infiltrates. Objective This study was conducted to scrutinize the clinical and histopathologic features of FMF in ...

Journal: :Oncology 2007
Alistair Robson

The diagnosis of cutaneous T-cell lymphoma (CTCL) requires accurate histopathology, including immunocytochemistry, as well as careful clinical appraisal and analysis for T-cell clonality. This paper reviews the key histologic features of mycosis fungoides (MF) and its variants, and of lymphomatoid papulosis (LyP). Mycosis fungoides is an epidermotropic CTCL that evolves through distinct disease...

Journal: :JOP : Journal of the pancreas 2008
Klaus Gottlieb Karl Anders Hakan Kaya

CONTEXT Cutaneous T-cell lymphomas such as mycosis fungoides are uncommon neoplasms with a long and often relatively indolent course. Some eventually metastasize to lymph nodes or visceral organs but there are to our knowledge only two prior reports which describe clinically relevant pancreas involvement. CASE REPORT We present the case of a 52-year-old man with mycosis fungoides who develope...

2015
Gil Bar-Sela Reuven Bergman

CTCL: cutaneous T-cell lymphoma CTLA4: cytotoxic T-lymphocyte antigen-4 MF: mycosis fungoides INTRODUCTION Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL). Immunostimulatory approaches, such as interferon administration, are well established in the treatment of CTCL. In the last years, several new antibodies that enhance the immune system activity have entered...

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