Lichen sclerosus is an inflammatory skin condition characterized by inflammation of the papillary dermis that leads to white scarlike plaques. It occurs classically in the genitals but also has extragenital manifestations with a variety of clinical presentations including a bullous variant. The purpose of this review is to characterize extragenital bullous lichen sclerosus, suggest that it may ...

Giant bullous emphysema, or vanishing lung syndrome, typically occurs in young, thin male smokers with large bullae in one or more upper lobes occupying at least one-third of the hemithorax. We present here a rare case of giant bullous emphysema in a mid-age nonsmoking female who was seen for progressive shortness of breath and cough. Chest computed tomography found a giant bulla in the middle ...

LABD: Linear IgA bullous dermatosis INTRODUCTION Linear IgA bullous dermatosis (LABD) is a rare disorder characterized by tense bullae arranged annularly on the trunk and extremities. LABD is usually idiopathic or associated with medications, classically vancomycin and nonsteroidal anti-inflammatory drugs. Rarely, LABD has been reported in association with lymphoproliferative disorders, sarcoma...

Erythema nodosum leprosum is characterised by brightly erythematous tender nodules or plaques usually in bilateral symmetrical distribution. ENL can also present in several atypical presentations like pustular, erythema multiform like, ulcerative, necrotic, panniculitic and bullous forms. Various precipitating factors for ENL include stress, pregnancy, surgery, lactation, menstruation, infectio...

Corneal collagen cross-linking with riboflavin and UVA light is a new therapeutic method for increase the biomechanical stability of the cornea through induction of new additional links between collagen fibers. The aim of this paper is to show the mechanism of action of this therapeutically method in different corneal diseases, for which this method can be applied: corneal ectasia, bullous kera...

Non-bullous congenital ichthyosiform erythroderma (NBCIE) is an autosomal recessive form of inherited icthyosis appears as fine white scales that gradually replace collodion membrane. This case report describes management of 5 years and 11-month-old child with NBCIE suffering from early childhood caries (ECC) under general anesthesia. How to cite this article: Choudhary R, Satish V. Dental Trea...

Sir, Pyoderma gangrenosum (PG) is an idiopathic neutrophilic dermatosis may occur in association with a wide variety of disorders, including inflammatory bowel disease, haematological and rheumatological conditions, and states of perturbed immune function. In addition to the classical ulcerative form of PG, less common variants exist. Among these, bullous PG was first described in 1972 as a pai...

Lichen planus pemphigoides (LPP) is an autoimmune disease characterised by evolution of subepidermal blisters on normal and lichen planus affected skin. We describe a case of LPP in a 54-year-old Chinese woman. The patient presented with psoriasiform plaques and was diagnosed with guttate psoriasis. Narrowband ultraviolet B (NBUVB) therapy was commenced, and she experienced a generalised erupti...

Dear Editor, Nicotinamide with tetracycline or doxycycline is used in the treatment of bullous pemphigoid. Nicotinamide is used in doses of 1500 to 2000 mg/day in divided doses in these cases. Nicotinic acid/laropiprant (Tredaptive®) is a lipid lowering agent which contains 1000 mg of nicotinic acid (niacin) and 20 mg of laropiprant which is a selective antagonist of prostaglandin D2 receptor. ...

Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-dependent cell-cell adhesion molecules which play an important role in the cell...