PURPOSE To determine the effect of ranibizumab on visual acuity (VA) following a 3-year treatment period for patients diagnosed with wet age-related macular degeneration. To establish whether baseline VA and injection frequency influence visual outcomes. PATIENTS AND METHODS Retrospective review of 70 patients (76 eyes) treated with 0.5 mg intravitreal ranibizumab for 3 consecutive months, an...

Protein tyrosine phosphatase-alpha (PTPalpha) is a widely expressed receptor-type phosphatase that functions in multiple signaling systems. The actions of PTPalpha can be regulated by its phosphorylation on serine and tyrosine residues, although little is known about the conditions that promote PTPalpha phosphorylation. In this study, we tested the ability of several extracellular factors to st...

Similarity search is one of the typical query type for multimedia retrieval, data mining and decision support systems. Many similarity measures transform objects into points in a high-dimensional vector space and deene similarity of two objects with respect to their distance in the vector space. Data-partitioning index methods for such spaces like R-tree or X-tree are known to deteriorate with ...