Polyampholyte-based films can be efficiently self-assembled onto a surface in a one-pot manner. By using a gradient of protons, morphogens, generated at an electrode surface, a charge-shifting polyelectrolyte present in solution can be transformed into a polyampholyte, leading to the continuous buildup of a film based on polyelectrolyte complexation.

Alzheimer's disease (AD) is the most common cause of dementia. There are currently no effective treatments that may delay the onset, slow the progression or prevent the disease. Unless such treatments are developed, the number of AD cases is expected to double in the next 30 years. There is overwhelming genetic and biochemical evidence that the aggregation and buildup of the amyloid-beta (Abeta...

The synthesis and characterization of a novel trityl-TEMPO biradical and the investigation of its properties as Dynamic Nuclear Polarization (DNP) polarizing agent are reported. Comparison with a structurally related monoradical (PTM-TEMPE) or mixtures of the two monoradical components reveals that the biradical has a much higher polarization efficiency and a faster polarization buildup. This o...

In this edition of Current Issues, we investigate whether concerns over the buildup of U.S. corporate debt are in fact justified. We examine the health of the nonfinancial corporate sector on a firm-by-firm basis, focusing chiefly on three key measures of health: leverage, liquidity, and overall solvency.1 Our analysis suggests that the sector as a whole is in good shape, and that its f inancia...

We report high-resolution saturated-absorption spectra recorded by use of a few microwatts of radiation generated in a single pass by difference-frequency mixing. These results were obtained without the use of buildup cavities for the nonlinear mixing or for the saturation spectroscopy. We show high-quality saturated-absorption signals for the fundamental rovibrational band of CO(2) near 4.3 mu...

[This corrects the article on p. 93 in vol. 8, PMID: 24808822.].

The current buildup of the U.S. Social Security Trust Fund has caused speculation about both the potential consequences of the buildup under different policy objectives and the fund's management. As is often the case, the search for precedents under similar circumstances abroad has been quite extensive on the part of legislators and U.S. experts in the field of financial policy. This article su...

Loss of fitness due to the accumulation of deleterious mutations appears to be inevitable in small, obligately asexual populations, as these are incapable of reconstituting highly fit genotypes by recombination or back mutation. The cumulative buildup of such mutations is expected to lead to an eventual reduction in population size, and this facilitates the chance accumulation of future mutatio...

Lagrangian statistics from millions of particles are used to study the turbulent entrainment mechanism in a direct numerical simulation of a turbulent plane jet at Re(λ) ≈ 110. The particles (tracers) are initially seeded at the irrotational region of the jet near the turbulent shear layer and are followed as they are drawn into the turbulent region across the turbulent-nonturbulent interface (...