carbon nanotubes (cnts) are high aspect ratio allotropes of carbon. because of their unique physical and chemical characteristics, they are nominated for a vast variety of applications in the biomedical field. their very low solubility is the only problem of them which is solved by different methods of functionalization. after discoveries in the last few years of the capacity of cnts to penetra...

in this work we synthesized of mesoporous silica nanoparticles and functionalized with 3-aminopropyltriethoxysilane to improve the loading and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample were characterized by fourier transform infrared spectroscopy, scanning electron microscopy , x-ray diffraction, and ultraviolet-visible. the fourier transform infrared spectroscopy resu...

topical and transdermal drug delivery systems are noninvasive and can be self-administered with the minimization of side-effects, have received increased attention during the past few years. nanoemulsions, emulsions sized between 20-200 nm with narrow distributions, offer several advantages for topical and transdermal delivery of pharmaceutical agents including controlled droplet size, the abil...

Corresponding Authors: Sellappan Velmurugan Email: [email protected] Abstract: Carrier technology offers a promising approach for drug delivery system by coupling the drug to a carrier particle such as microspheres,nanoparticles, niosomes, liposomes etc. which modulates the release characteristics of the drug. Mucoadhesion had been a topic of interest in the design of novel drug delive...

Certain agents that enhance drug transport through the skin, including surfactants, bile salts, and fatty acids, have been shown to exert a similar effect on the oral mucosa. Oral drug delivery offers an attractive method of needle-free drug administration. Unfortunately, oral delivery is often hampered by the poor permeability of drugs across the intestinal epithelium. Although several single ...

The two major problems in the development of new drugs are low aqueous solubility and oral bioavailability. Although, drug delivery via route is most preferred for years but it also has some drawbacks. Various techniques improving have been developed, however success these depends on physical chemical properties under development. In recent years, mucoadhesive gained high popularity comparison ...

Purpose: The aim of the present study was to enhance oral bioavailability curcumin using different surfactant and vehicle for preparing proniosomal gel. Methods: Curcumin comes under BCS Class IV which is having low solubility permeability poor bioavailability. Buccal drug delivery can bypass such problems leads increase in Proniosomes offer excellent potential improved through versatile routes...

recently, specific attention has been paid to aptamers, short dna or rna, as a tool for cancer diagnosis and therapy. in the present study mcs nanogels were prepared by myristate: chitosan at 1:9 ratio and were characterized by several techniques. a selected ssdna aptamer(apt) capable of detecting lncap cells was linked to myristilated chitosan nanogels (apt-mcs) by glutaraldehyde and loaded wi...

a multiple-unit oral floating system was prepared using the emulsification-solvent diffusion method to prolong the gastric emptying time of theophylline. for this purpose, theophylline, ethyl cellulose and dibutyl phthalate were dissolved in an ethanol/dichloromethane mixture, added to 0.1 m hcl containing nacl (20%) or saturated theophylline and/or different concentrations of polysorbate 80 an...