Biotechnological drugs (BTDs) are complex molecules whose manufacturing process precludes the ability to identically reproduce the structure of the original product, and therefore there cannot be an absolute equivalence between the original (innovative) medication and its biosimilar counterpart. BTDs have been proven useful in the treatment of several rheumatic diseases, however their high cost...

With a view on improving user perceived performance on networks supporting elastic flows, e.g., multimedia/data file transfers, we identify the key properties that an online dynamic bandwidth allocation policy should have. We then propose a family of bandwidth allocation criteria which depends on the residual work of on-going transfers. Analysis and simulations show that allocating bandwidth in...

Abstract This paper presents a novel approach to developing 2D structural theories for composite shells. The proposed uses the capabilities of Carrera Unified Formulation (CUF) in conjunction with Axiomatic/Asymptotic Method (AAM) obtain best given layouts. Different cases are considered analyze influence factors such as boundary conditions, lamination, and thickness on accuracy model. paramete...

A PVC membrane Cr(III) ion selective electrode has been constructed using 2H-1,4-benzothioazine-2,3(4H)dione dioxime (BTD) as membrane carrier. The influence of membrane composition on the electroderesponse was studied. The electrode exhibits a Nernstian response over a Cr(III) concentration range of 1.0 x10 6 to 1.0>< 10-1 M (r = 0.99) with a slope of 19.5 ± 0.5 mV per decade of concentration,...

Setiap sektor mempunyai kontribusi terhadap penerimaan negara berupa pajak. Beberapa peraturan perpajakan yang spesifik dan berbeda dibanding dengan lainnya. Hal tersebut membuat adanya perbedaan startegi manajemen pajak pada tersebut. Aktifitas penghindaran dapat mengurangi pendapatan dari Penelitian ini adalah menguji apakah terdapat dilakukan oleh setiap ada di Bursa Efek Indonesia. Metode p...

Seventeen of twenty-three species of groupers collected from the western Atlantic Ocean and adjacent waters were infected with 19 identified species (13 new) of Pseudorhabdosynochus Yamaguti, 1958 (Dactylogyridea, Diplectanidae); specimens of the Spanish flag Gonioplectrus hispanus, coney Cephalopholis fulva, marbled grouper Dermatolepis inermis, mutton hamlet Alphestes afer, and misty grouper ...

Diplectanid monogeneans are gill parasites that can infect fish in huge numbers and thus become harmful, especially in maricultured fish. It is therefore useful to have taxonomic tools, such as keys, to identify species. The following diplectanid species from groupers of the Mediterranean Sea were studied: five species of Pseudorhabdosynochus Yamaguti, 1958, including P. riouxi (Oliver, 1986) K...

In eukaryotic cell nuclei, DNA associates with the core histones H2A, H2B, H3 and H4 to form nucleosomal core particles. DNA binding to histones is regulated by posttranslational modifications of N-terminal tails (e.g., acetylation and methylation of histones). These modifications play important roles in the epigenetic control of chromatin structure. Recently, evidence that biotinidase and holo...