The structure of the natural anticoagulant, heparin, is gradually being elucidated. As each step forward is made, attempts to synthesize molecules with the biological activity of heparin receive renewed impetus. It is now known (Jorpes, 1939) that heparin is composed of glucuronic acid and glucosamine though the mode of linkage of these two parts is not yet clear. Some of the hydroxyl groups of...

Previously published methods for the preparation of the pyrimidine nucleotides are relatively involved procedures requiring either repeated crystallization of the brucine salts (1) or fractionation of the free acids by their differential solubility in pyridme (2). Although the yields obtained by the former method were not published, we have isolated less than 2 per cent of the original nucleic ...

The purpose of this study was to determine whether there is a well-defined allosteric site on the human a2A-adrenergic receptor. To explore this question, we examined the effects of amiloride analogues on the dissociation of [H]yohimbine, [H]rauwolscine, and [H]RX821002. The dissociation data fitted well to an equation derived from the ternary complex allosteric model with amiloride analogue co...

Thomas Anderson (1819-1874), a physician turned chemist, did most of his research in organic chemistry. He discovered butylamine, collidine, lutidine, picoline, and pyridine during the pyrolysis of coal and destruction of bone oil, studied the constitution of anthracene, piperidine, and codeine; the analysis and properties of alkaloids derived from opium, and prepared a large number of new deri...