In the hydrologic analysis of extreme events such as precipitation or floods, the data can generally be divided into two types: partial duration series and annual maximum series. Partial duration series analysis is a robust method to analyze hydrologic extremes, but the adaptive choice of an optimal threshold is challenging. The main goal of this paper was to determine the best method for choos...

In the last decade, many systemic therapies have become available to improve survival in the setting of castration-resistant prostate cancer. Once effective treatments for advanced and incurable disease have been established, these agents are generally explored in the adjuvant and neoadjuvant settings to evaluate their role in increasing the chance of cure for localised disease. Clinical trials...

Epidemiologic studies of rheumatic diseases can be broadly divided into those that describe the occurrence of specific disorders, those that attempt to quantify the role of putative risk factors for disease occurrence, and those that define the outcome and factors associated with it. Studies in this area have tended to be hypothesis testing rather than generating new etiologic or related hypoth...