Eremostachys pulvinaris (family: Labiatae), one of the 60 species of the genus Eremostachys, occurs mainly in central Asian countries, e.g. Iran, Armenia, Ashgabad and the USSR. The rhizomes of this plant were collected from Tabriz in Azarbaijan province during September-October 2003. There is no report on any previous phytochemical investigation on E. pulvinaris available todate, phytochemical...

The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 microg/mL set for potential molluscicidal activity by the...

Psidium guineense Swartz is a shrub native to Brazil. It is consumed in natura or in the form of pulp, which presents a high content of C vitamin and proteins. The chemical prospection of the aqueous extracts from unripe and mature pulp revealed the presence of tannins and flavonoids. The extracts demonstrated moderate antibacterial activity against the most of strains tested, and the best resu...

Three steroids, namely 24-ethyl-5α-cholestan-3-one (1), 5α-stigmast-22-en-3-one (2), stigmast-5, 22-dien-3-one (3) have been isolated from N. stellata. The phytochemical and antimicrobial as well as cytotoxic activities of Nymphaea stellata were investigated in this study. Crude extracts of N. stellata and various column fractions exhibited poor antimicrobial activity against a wide range of Gr...

Lupeol (1), epilupeol (2) and β-sitosterol (3) were isolated from the n-hexane and the carbon tetrachloride soluble fraction of a methanol extract of the leaves of Phoenix paludosa Roxb. The n-hexane, carbon tetrachloride and chloroform soluble materials from the concentrated methanol extract were subjected to antimicrobial screening and brine shrimp lethality bioassay. All of the partitionates...

A marine soft coral species of the genus Heteroxenia collected from Mindoro Island, Philippines yielded two cadinene sesquiterpenes, (+)-alpha-muurolene (1) and a novel derivative (+)-6-hydroxy-alpha-muurolene (2), as well as the biologically active polyhydroxysterol, sarcoaldosterol A (3). The structure of the novel compound was unambiguously established on the basis of NMR spectroscopic (1H, ...

Three new indolediketopiperazine peroxides, namely, 24-hydroxyverruculogen (1), 26-hydroxyverruculogen (2), and 13-O-prenyl-26-hydroxyverruculogen (3), along with four known homologues (4-7), were isolated and identified from the culture extract of the marine sediment-derived fungus Penicillium brefeldianum SD-273. Their structures were determined based on the extensive spectroscopic analysis a...

In the aim of searching for new antifungal products from marine origin, we have isolated a sphingosine derivative, (9Z)-2-amino-docos-9-ene-1,3,13,14-tetraol (Haliscosamine) from the Moroccan sea sponge Haliclona viscosa using bio-guided (antifungal) HPLC methods. The molecular structure of this compound was elucidated by spectrometric techniques IR, UV, MS and NMR. The isolated metabolite show...

The plant Spondias pinnata (Linn. f.) Kurz belonging to Anacardiaceae family, is used as a medicinal agent in Bangladesh. In the present investigation, attempt was undertaken to study the antibacterial potency and cytotoxic activity of 80% ethanol extract of its fruit. The antibacterial activity was performed by the disc diffusion method and cytotoxicity was observed by brine shrimp lethality b...

Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and L-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addit...