The developmental transcription factor SOX4 contributes to the metastatic spread of multiple solid cancer types, but its direct target genes that mediate cancer progression are not well defined. Using a systematic molecular and genomic approach, we identified the TMEM2 transmembrane protein gene as a direct transcriptional target of SOX4. TMEM2 was transcriptionally activated by SOX4 in breast ...

chromanone derivatives demonstrate remarkable cytotoxity against a varieties of cancer cell lines. novel 9-[hydroxy(substitutedphenyl)methyl]-2,2-dimethyl-2,3,8,9- tetrahydro-4h,10h-pyrano[2,3-f]chromene-4,10-diones as glyasperin analogues were synthesized in four steps from known 4-chromone 1. the key step was the preparation of chromane dione 5a by regioselective intramolecular cyclization re...

A respective number of pigeon and quail were purchased from Churkhai Bazar, Mymensingh at their marketing weight to compare yield quality characteristics meat. The birds then slaughtered the meat compared against live weight. samples breast, thigh drumstick kept 4°C for 24 hours. Findings reveal that thigh, drumstick, head, liver, gizzard, heart, neck shank% significantly higher in but feather ...

In this study molecular topology based QSAR has been applied to predict the reaction yield and anticancer activity of 18 imidazole and guanidine derivatives. Four properties were evaluated, namely reaction yield, anti prostatic-cancer activity, anti breast-cancer activity and anti lung-cancer activity. The four models have been validated by both internal and cross validation, and also by random...

The relationship between the severity of footpad dermatitis (FPD) and growth performance parameters (live weight, condemnation rate, leg meat yield and breast meat yield) was investigated in a total of 63 million broiler chickens that were processed over a period of 1,053 days between 2008 and 2012 at a full-scale processing plant in Kagoshima Prefecture, Japan. FPD scores and carcass data were...

We investigated marinade absorption and physicochemical characteristics of vacuum-aged duck breasts that were halved and individually vacuum-packed for chiller aging at 4°C for 14 d. One half was marinated for 0, 7, or 14 d, while the second half was used as a control. Marinade absorption, cooking loss, cooking yield, texture profile, pH, color, protein solubility, and thiobarbituric acid react...

objective: to assess the level of awareness on breast cancer among women of reproductive age. materials and methods: a cross-sectional descriptive study was conducted in opd of dhaka medical college hospital among the 175 respondents by face to face interview using pretested semi structured questionnaire. results: one forth (23%) aged 21-25 years, mostly muslim (86.3%), housewives (72.57%), had...

The procedures used to diagnose, stage, and treat breast disease are rapidly becoming less invasive and more cosmetically satisfying while remaining oncologically sound. In particular, percutaneous core biopsy has largely replaced excisional breast biopsy for both palpable and nonpalpable breast lesions and has proved to be an equally accurate, less invasive, and less costly means of pathologic...