The inflammatory microenvironment affects breast cancer progression. Proteins that govern the inflammatory response are secreted into the extracellular space, but this compartment still needs to be characterized in human breast tissues in vivo. Dense breast tissue is a major risk factor for breast cancer by yet unknown mechanisms and no non-toxic prevention for these patients exists. Here, we u...

Background The Aurora kinase family is comprised of highly conserved serine/threonine protein kinases that are known to be crucial in the regulation of the cell cycle. Aberrant expression of Aurora kinases has been demonstrated in certain malignancies. We aimed to examine the expression of Aurora kinases in human breast cancer tissues and to investigate the cellular impact of Aurora kinases inh...

BACKGROUND A new diagnostic and prognostic biomarker may be of value in cancer diseases. Our study aimed to evaluate the CDKN1A/p21 and TGFBR2 level measurable in a cohort of patients with breast cancer after mastectomy, and to confirm their suitability to serve as prognostic biomarkers of the cancer. METHODS The expression levels of CDKN1A/p21 and TGFBR2 were detected by reverse transcriptio...

Fibroadenoma is a common benign tumour of female breast. It’s growth which consist fibrous and glandular tissues. Treatment options include watchful waiting surgical removal. Surgical removal fraught with high incidence its recurrence. This article reviews what known about Fibro adenoma formation management. By homoeopathy treatment there will be reduction in the size tumour, helps to dissolve ...

PURPOSE There is compelling evidence of a relationship between poly(ADP-ribosyl)ation and tumorigenesis; however, much less is known about the role of specific targets of poly(ADP-ribosyl)ation in tumor development. Two forms of the multifunctional transcription factor, CTCF, were previously identified: a 130-kDa protein (CTCF-130), characteristic for cell lines, and a 180-kDa protein (CTCF-180...

Breast cancer is one of the leading causes death among women; to decrease rate for this disease, early detection plays a key role. Recently, microwave imaging systems have been proposed as an alternative current techniques, but they suffer from poor resolution due low frequencies involved. In paper, first time, innovative millimeter-wave system early-stage breast and experimentally verified on ...

The leukocyte migration test (LMT) reactivity of breast cancer patients to Rill murine mammary tumor virus (MuMTV) gp55 was studied and compared with simulta neous reactivity to the following: (a) RIM gp55 prepared in another laboratory; (b) gp68, gp34, and p28 of Rill MuMTV; (c) gpSO of A-strain MuMTV; (d) gp70 and gp45 of Rauscher leukemia virus; and (e) autologous and homol ogous lymphoretic...

Krüppel-associated box-containing zinc finger proteins (KRAP-ZFPs) are well recognized as key regulators of transcription, which play a crucial role in the regulation of cell proliferation, differentiation, apoptosis and tumorigenesis. We previously identified a KRAP-ZFP protein ZNF545 acting as a tumor suppressor involved in tumor pathogenesis. However, its expression and biological function i...

We found that microRNA-320a (miR-320a) was an attractive prognostic biomarker in breast cancer (BC) previously, whereas its regulatory mechanism in BC was not well understood. Our aim was to identify miR-320a target gene, examine the clinical relationship between miR-320a and its target, and further explore the functions of its target in BC. In this study, miR-320a downstream target gene was de...

BACKGROUND We evaluated the prognostic significance of KLK10 exon 3 methylation in patients with early-stage breast cancer since it has been shown to have a significant impact on biological characteristics of breast tumors. MATERIALS AND METHODS Using methylation-specific PCR, we evaluated the specificity of KLK10 methylation in 10 breast tumors and matching normal tissues, 10 breast fibroade...