background: chemokine receptors have been shown to play an important role in the development and metastatic spread of various malignancies. in this study, the gene expression profile of some key chemokine receptors involved in metastasis has been investigated in esophageal and breast cancer cell lines.   methods: in a descriptive study, gene expression profile of ccr1, ccr6, ccr7, ccr9, cxcr1, ...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

a bstra ct background: annually, about 6000 new cases are diagnosed with breast cancer in iran. in iran, more women are affected with breast cancer than a decade earlier in comparison with other countries, and 70% of them are diagnosed at an advanced phase. insomnia is the most common disorder following breast cancer, and interference in sleep quality and rest causes changes in physiological fu...

introduction: breast cancer is the most common cancer and the second cause of death in women. it is essential to have the highest level of confidence in axillary staging assessment. many surgeons and pathologists believe that fewer lymph nodes are present in axillary dissection specimens of women treated by neoadjuvant chemotherapy. consequently, the purpose of this study was to compare the lym...

Background/Aim: Multifocal breast cancers (MFBCs) still have undiscoverable clinical significance. Being the standard surgical management for early cancer, implementation of breast-conservation therapy (BCT) as a procedure multifocal is questionable and needs solid basis evidence via prospective randomized control trials. Methods: A study was conducted on female patients with operable cancer ex...

BACKGROUND Positive margins after breast conservation surgery occur frequently and negatively influence local control rates. HYPOTHESIS Preoperative breast ultrasonography reduces the incidence of positive margins during breast conservation surgery. DESIGN Case-control analysis. PATIENTS AND INTERVENTION One hundred twenty-two consecutive patients with invasive breast cancer were studied....

BACKGROUND Adjuvant radiation therapy is commonly administered to breast cancer patients who received breast-conserving surgery. However, lengthy treatment times of standard radiotherapy pose certain challenges. Here, we performed a prospective controlled study comparing standard radiation to hypofractionated radiotherapy in terms of efficacy and outcome. MATERIAL AND METHODS Eighty breast ca...

CONTEXT Breast cancer is the most prevalent cancer amongst women but it has the highest survival rates amongst all cancer. Rehabilitation therapy of post-treatment effects from cancer and its treatment is needed to improve functioning and quality of life. This review investigated the range of methods for improving physical, psychosocial, occupational, and social wellbeing in women with breast c...

The purpose of this planning case report is to share the perceived dosimetric benefits of innovative hybrid volumetric modulated arc therapy (h-VMAT) for bilateral breast cancer radiotherapy in two patients with synchronous bilateral breast cancer. Two patients with early bilateral breast cancer after breast conservation surgery and adjuvant chemotherapy were planned for bilateral breast radiot...