Endothelium differentiates in response to tissue-specific signals; brain endothelium expresses tight junctions and transporters which are absent from other endothelia. The promoter of the tight junction protein occludin exhibited strong activity in a brain endothelial cell line, hCMEC/D3 but was inactive in lung endothelial cells. Expression of occludin in brain endothelium corresponded with bi...

The guidelines are the pivotal area of the website. The available guidelines focus on pre-hospital management, general management of TBI, management of TBI in children and adolescents and surgical management. The first three are from 2000 and are thus a little dated, although an interim update was posted in 2003 and full updates are underway from this April. All the guidelines are based on thor...

As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood-brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, w...

optic neuritis an inflammatory disorder of the optic nerve inflammation is usually in young’s with symptoms of eye pain and vision loss that occurs is a common symptom of ms. optic neuritis is one of the first symptoms of ms that observable into disorders in white matter of cerebral cortex. the risk of ms in patients with optic neuritis during 2 years 20% in 15 years, 45-80% is calculated. ‏in ...

low frequency stimulation (lfs) is a potential alternative therapy for epilepsy. however, it seems that the anticonvulsant effects of lfs depend on its target sites in the brain. thus, the present study was designed to compare the anticonvulsant effects of lfs administered to amygdala, piriform cortex and substantia nigra on amygdala kindling acquisition. in control group, rats were kindled in ...

background: angiotensin ii (ang ii) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. this study evaluated the role of central ang ii by using candesartan, as an at1 receptor blocker, in the brain edema formation and blood-brain barrier (bbb) disruption caused by ischemia/reperfusion (i/r) injuries in rat. methods...

neurofeedback is a kind of biofeedback, which teaches self-control of brain functions to subjects by measuring brain waves and providing a feedback signal. neurofeedback usually provides the audio and or video feedback. positive or negative feedback is produced for desirable or undesirable brain activities, respectively. in this review, we provided clinical and technical information about the f...

Brain connectomics research has rapidly expanded using functional MRI (fMRI) and diffusion-weighted MRI (dwMRI). A common product of these varied analyses is a connectivity matrix (CM). A CM stores the connection strength between any two regions ("nodes") in a brain network. This format is useful for several reasons: (1) it is highly distilled, with minimal data size and complexity, (2) graph t...

Potent cannabinoid CB1 receptor ligands include anandamide [N-(2-hydroxyethyl)arachidonamide], Delta9-tetrahydrocannabinol, and 3H-CP 55,940 at the agonist site and selected organophosphorus esters (including some pesticides) and organosulfur compounds at a proposed closely coupled "nucleophilic" site. This study considers the toxicological and structural features of alkylfluorophosphonates, be...

evidence acquisition a systematic literature searching of databases medline, embase, and google scholar was done from 1982 and updated in december 2015. search terms were “cholecystectomy”, “laparoscopic cholecystectomy”, “four port laparoscopic cholecystectomy”, “single-incision laparoscopic surgery”. context laparoscopic approach with its several techniques has become the standard method for ...