Positron emission tomography (PET) is an imaging technology used to visualize distribution of particular ligands inside living organisms. The ligand is labeled by a positron-emitting isotope, such as 11C, 15O, 13N and 18F, and injected into subjects. By detecting γ-rays emitted from the ligand, in vivo biodistribution and kinetics of the ligand can be depicted with high sensitivity. By altering...

Mitochondrial dysfunction mainly affects organs with high metabolic demand, primarily the brain. Epilepsy is a common phenotypic sign of both syndromic and non-syndromic mitochondrial diseases. in diseases poorly treatable often an unfavorable prognostic sign. Patients epilepsy are prescribed various anti-seizure medications. Mitochondriotoxic drugs should be avoided. Descriptions MELAS-syndrom...

Brain is the control center of the body. It controls each and every stimulus in the body. Disease is an impairment of health or a condition of abnormal functioning of our body. The cause of disease is either external like infectious diseases may be an internal disease such as auto immune diseases. Some of these are fatal. There are many deadliest diseases in human one among them is Brain diseas...

Molecular cytogenetics is a promising field of biomedical research that has recently revolutionized our thinking on genome structure and behavior. This is in part due to discoveries of human genomic variations and their contribution to biodiversity and disease. Since these studies were primarily targeted at variation of the genome structure, it appears apposite to cover them by molecular cytoge...

I. The blood-brain barrier . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 A. Morphology and function. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 B. Mechanisms of transport of compounds across the blood-brain barrier . . . . ....

The brain vasculature has several specific features, one of them being the blood-brain barrier (BBB), which supports and protects by allowing for passage oxygen nutrients, while at same time preventing pathogens toxins. BBB also prevents efficient delivery drugs to brain, e.g. treatment tumors. In murine perivascular fibroblasts were recently identified as a novel potential constituent BBB. Her...

Increases and decreases of synaptic activity in the brain are accompanied by proportional changes in capillary perfusion and local glucose consumption. These changes in glucose consumption are the effect of changed activity or density of the afferent nerve terminals in that region. Loss of neurons may result in decreased glucose consumption in distant brain regions by deafferentiation, while al...

Movement Disorder Disease (MDD) is one general type of diseases that severely impair human motor ability and reduce the body controllability. Over millions of people in North America are suffering from these diseases and Parkinson's disease (PD) is one of the most typical and common among them. PD is the second most prevalent neurodegenerative disease, affecting over 500,000 people in America a...

Most intrauterine infections are acquired through the placenta, although transvaginal bacterial infections may also occur. The TORCH eponym remains a good reminder for these entities, identifying toxoplasmosis, others, rubella, cytomegalic virus, and herpes simplex. A second H for HlV or perhaps the words A (AIDS) TORCH should now be used, as AIDS becomes the most common maternally transmitted ...