Seyed Khashayar Mirbahaeddin, Aryan Aarabi, Mahdi Haghshenas, Faezeh Eslami, Saba Mardeh Katani, Leila Kia, Niloufar Bahrampour, Fariba Ghorbani, Mojtaba Mokhber Dezfoli. Korean J Transplant 2022;36:224. https://doi.org/10.4285/ATW2022.F-3603

BACKGROUND Due to the loss of autonomic nervous system, precise control of the hemodynamic status in dead brain potential donors presents a clinical dilemma. In these patients, due to head trauma and cerebral edema, fluids administration is restricted. Moreover, the decreased central venous pressure may put the viability of the organs at risk. OBJECTIVE To investigate hemodynamic factors affe...

Worldwide, the number of patients wait-listed for organ transplantation is growing. In most countries, however, there is a shortage of donor organs. Switzerland has one of the lowest post mortem donation rates among European countries. While most organs donated for transplantation are retrieved from primary or secondary brain-dead donors with sustained circulation (heart-beating donors), organ ...

UNLABELLED The removal of apoptotic cell corpses is important for maintaining homeostasis. Previously, defects in apoptotic cell clearance have been linked to neurodegeneration. However, the mechanisms underlying this are still poorly understood. In this study, we report that the absence of the phagocytic receptor Draper in glia leads to a pronounced accumulation of apoptotic neurons in the bra...

Little is known about spinal visceral reflexes in brain-dead man, although they have been described in experimental animals. In 1983, 25 brain-dead individuals were observed during donor nephrectomy. It was confirmed that some of these donors, without higher centre modulation and not under significant pharmacological influence, had viscero-somatic motor reflexes and viscero-visceral cardiovascu...