BACKGROUND The presence of hypovitaminosis D in patients with autoimmune bullous skin diseases, such as pemphigus vulgaris (PV) and bullous pemphigoid (BP), is debated. In a previous study we found an increased prevalence of vertebral fractures (VFx) and hypovitaminosis D in PV and BP patients. The present study extends the sample size of the previous one, for investigating the 25-hydroxyvitami...

An amphoteric rinse used in the emergency treatment of a serious ocular burn Max Gerard a,∗, Harold Merle b,1, Frédérick Chiambaretta c,2, Danièle Rigal c,3, Norbert Schrage d a Service d’Ophtalmologie, Centre Hospitalier de Cayenne, Rue des Flamboyants, 97300 Cayenne, Guyane Française, France b Service d’Ophtalmologie, Centre Hospitalier Universitaire de Fort de France, Hôpital Pierre Zobda Qu...

OBJECTIVES the results of experimental studies suggest that vitamin D deficiency activates the renin-angiotensin system and predisposes to hypertension. Results of previous epidemiological studies investigating the association between 25-hydroxyvitamin D [25(OH)D] status and hypertension have not been consistent, perhaps because of their sole reliance on office blood pressure (BP) measurements ...

We surveyed sequence variation and divergence for the entire 5972-bp transcriptional unit of the white gene in 15 lines of Drosophila melanogaster and one line of D. simulans. We found a very high degree of haplotypic structuring for the polymorphisms in the 3' half of the gene, as opposed to the polymorphisms in the 5' half. To determine the evolutionary mechanisms responsible for this pattern...

Let B be any set of n axis-aligned boxes in R, d ≥ 1. For any point p, we define the subset Bp of B as Bp = {B ∈ B : p ∈ B}. A box B in Bp is said to be stabbed by p. A subset N ⊆ B is a (1/c)-net for B if Np 6= ∅ for any p ∈ R such that |Bp| ≤ n/c. The number of distinct subsets Bp is O((2n)), so the set system described above has so-called finite VCdimension d. This ensures that there always ...

The accuracy and precision of 3 lactation models was estimated by summarizing means and variability in projection error for next-test milk and actual 305-d milk yield (M305) for 50-d intervals in a large Dairy Herd Improvement Association data set. Lactations were grouped by breed (Holstein, Jersey, and crossbred) and parity (first vs. later). A smaller, single-herd data set with both Dairy Her...

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Blockade of brain m-opioid receptor (m-OR) and d-opioid receptor (d-OR) was investigated in recently abstinent alcohol-dependent subjects (N1⁄4 21) maintained on naltrexone. Subjects completed a 19-day inpatient protocol, which included alcohol abstinence followed by naltrexone treatment (50 mg) on days 15–19. Blood samples were collected after the first administration of naltrexone to evaluate...

We examined the relative contribution of renin-angiotensin system blockade and bradykinin potentiation to the renal hemodynamic effect of the angiotensin converting enzyme inhibitor enalaprilat in sodium-deprived dogs. Six conscious dogs instrumented for monitoring of blood pressure (BP) and renal blood flow (RBF) were employed in five groups of experiments. In group 1, enalaprilat alone was ad...