In the process of neuronal inflammation, an increased in inflammatory cytokines (IL-1β, IL-6 and TNF-α) from immune cells (leukocytes and macrophages), brain cells (microglia, astrocytes and neurons) and in hippocampus, amygdala occurs. Raise the level of cytokines result in reduced in production of molecules that are related to plasticity, especially BDNF, IGF-1 and VEGF. Microglia ...

Background and Aims: The therapeutic effects of the olibanum, the resin of Boswellia serrata (B. serrata) from the Burseraceae family in inflammatory disease have been reported. There are more than 200 active ingredients in this resin, including Boswellic acid. It is proposed that aqueous extract of B. serrata can improve memory impairment induced by cerebral inflammation result in the adminis...

Calotropis gigantea (Linn) and Amoora rohituka (Roxb.) have long been used in folkloric medicine for the treatment of various ailments in Bangladesh. The present study was designed to investigate the cytotoxicity of isolated compounds from these two plants. Two compounds, named β-boswellic acid (compound-1) and 2-methoxy-14-calamenenone (compound-2) were isolated from the flowers of Calotropis ...

Physiological studies confirm improvement of memory by Olibanum, a resin from Boswellia species, while little is known about the molecular mechanism by which it affects memory performance. Two master transcription factors, CREB-1 and CREB-2, regulate downstream memory-related genes expression, leading to the long-term memory potentiation. This study addresses the effects of Beta-boswellic acid ...

INTRODUCTION Osteoarthritis is a chronic rheumatoid disease mediated by metalloproteinases and inflammatory cytokines. Methylsulfonylmethane (MSM) and boswellic acids (BA) each show promise in the treatment of inflammatory processes, but the efficacy of combined treatment with these substances in the treatment of arthritis has not yet been studied. METHODS In this prospective randomized clini...

Frankincense, the oleogum resin from Boswellia sp., has been an early luxury good in both Western and Eastern societies and is particularly used in Christian funerary and liturgical rites. The scant grave goods in late medieval burials comprise laterally perforated pottery vessels which are usually filled with charcoal. They occur in most regions of western Europe and are interpreted as incense...