INTRODUCTION Arthritis induces joint erosions and skeletal bone fragility. OBJECTIVES The main goal of this work was to analyze the early arthritis induced events at bone architecture and mechanical properties at tissue level. METHODS Eighty-eight Wistar rats were randomly housed in experimental groups, as follows: adjuvant induced arthritis (AIA) (N = 47) and a control healthy group (N = 4...

Introduction Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation, subchondral bone sclerosis and osteophyte formation. Recent studies have demonstrated that an increase in subchondral bone turnover is accompanied by specific architectural changes in the trabecular bone in OA joints. Furthermore, epidemiological studies have demonstrated positive ...

Osteocalcin or bone gamma-carboxyglutamic acid (gla) protein and Bone-specific alkaline phosphatase (b-AP) total protein levels were evaluated as indicators of bone turnover in twenty patients with sickle cell haemoglobinopathies and in twenty normal healthy individuals. The serum bone-specific alkaline phosphatase total protein level was measured by immunoradiometric (IRMA) method. The concent...

Ghrelin is released in response to fasting, such that circulating levels are highest immediately prior to meals. Bone turnover is acutely responsive to the fed state, with increased bone resorption during fasting and suppression during feeding. The current study investigated the hypothesis that ghrelin regulates the activity of bone cells. Ghrelin increased the bone-resorbing activity of rat os...

Osteoporosis is a common disease with features of gradual loss of mineral content and bone mass. Pathologic fracture may occur in the vertebrae, femur, radius, and even mandible. Bone loss during the early stages of oestrogen deficiency is clearly associated with increased bone turnover. Oestrogen treatment has a bone-protective effect associated with decreasing bone turnover in ovariectomised ...

Bone strength - and, hence, fracture risk - reflects the structural and material properties of the skeleton, which changes with bone turnover during aging and following effective pharmacotherapy. A variety of powerful new techniques (quantitative computed tomography, as well as peripheral quantitative computed tomography and high-resolution peripheral quantitative computed tomography) provide p...

Type I collagen is the major bone protein. Little is known quantitatively about human bone collagen synthesis in vivo, despite its importance for the understanding of bone formation and turnover. Our aim was to develop a method that could be used for the physiological and pathophysiological investigation of human bone collagen synthesis. We have carried out preliminary studies in patients under...