BACKGROUND AND AIMS It is known that people affected by osteopenia/osteoporosis can benefit from an adequate amount of physical activity, counteracting the progressive loss of bone and muscle mass caused by aging. Moreover, there is increasing evidence that exercise has positive effects on bone structure. The aim of our study was to evaluate the effects on bone tissue and muscular strength of a...

BACKGROUND For a tendon graft to function as an anterior cruciate ligament, the tendon must heal to the bone tunnel. We studied the effect of 4 weeks of implantation on the strength and stiffness of a tendon in a bone tunnel using two different fixation devices in an ovine model. HYPOTHESIS The type of fixation device in anterior cruciate ligament reconstruction may affect early healing, whic...

Background: For a tendon graft to function as an anterior cruciate ligament, the tendon must heal to the bone tunnel. We studied the effect of 4 weeks of implantation on the strength and stiffness of a tendon in a bone tunnel using two different fixation devices in an ovine model. Hypothesis: The type of fixation device in anterior cruciate ligament reconstruction may affect early healing, whic...

Predicting pathologic fractures of long bones caused by metastatic disease continues to be a challenging clinical problem. We assessed the ability of noninvasive imaging and computational techniques to predict the strength of bones with osteolytic lesions. A murine model of induced tumor osteolysis to the distal femur was used as a model system resulting in a wide range of lesion sizes. Microco...

In this study, we examined the therapeutic potential of anti-Sclerostin Antibody (Scl-Ab) and bisphosphonate treatments for the bone fragility disorder Osteogenesis Imperfecta (OI). Mice with the Amish OI mutation (Col1a2 G610C mice) and control wild type littermates (WT) were treated from week 5 to week 9 of life with (1) saline (control), (2) zoledronic acid given 0.025mg/kg s.c. weekly (ZA),...

from Bone 15 (4) 393-399 1994 Sodium fluoride has for more than 2 decades been a commonly used therapeutic agent for established osteoporosis because of a repeatedly documented anabolic effect on trabecular bone mass. Recently, however, three controlled trials have failed to demonstrate any therapeutic advantage of NaF over placebo with respect to vertebral fracture rate. Also, there have been ...

Introduction: With aging, there are well-documented changes in the structure and strength of the human skeleton. Periosteal and endocortical expansion of the diaphyses lead to increased moments of inertia, a positive geometric change that is offset partly by decreased cortical bone material strength. Trabecular bone density decreases with aging leading to loss of bone strength at sites rich in ...

INTRODUCTION Despite its origins in the mid-1950s with a bone adhesive called Ostamer [1], the development of bone adhesives is still in its early stages and is not a mature field. There lacks a consensus on aspects of adhesive performance and bond strength measurement. As a result, there are not standard tests for quantifying and evaluating the adhesive strength at the interface between the bo...

Background. Studies on bone effects of long-term substitution therapy with levothyroxine (LT4) have shown discrepant results. Previous studies have, however, not evaluated volumetric bone mineral densities (vBMD), bone structure, and strength using high resolution peripheral quantitative computed tomography (HR-pQCT) and finite element analysis (FEA). Using a cross-sectional design, we aimed to...