The intriguing notion of the menstrual cycle's having an acute impact on bone metabolism is examined as an expression of estrogen changes manifest as fluctuations in calcium-regulating hormones or biomarkers of bone formation/resorption. The effects of estrogen, progesterone, androgens, and follicle-stimulating hormones on bone health are also reviewed here. To date, the balance of evidence sug...

UNLABELLED The purpose of this study was to describe the clinical presentation of bone metastases in patients with carcinoid tumors and to determine the diagnostic value of imaging techniques and markers of bone metabolism. METHODS This retrospective study was performed on the entire group of patients with carcinoid tumors treated in our hospital from January 1992 to May 1999. Only patients w...

Despite numerous genetic studies on bone metabolism, understanding of the specific mechanisms is lacking. We developed an efficient screening system to identify novel genes involved in bone metabolism using mutant mouse strains registered with the Exchangeable Gene Trap Clones (EGTC) database. From 1278 trap clones in the EGTC database, 52 candidate lines were selected in the first screening, d...

This study aimed to investigate whether carbamazepine, sodium valproate or phenobarbital as monotherapy in ambulatory epileptic children with adequate sun exposure have some effect on their bone metabolism based on the determination of total serum alkaline phosphatase (AP) levels and its bone isoenzyme activity. Blood samples were obtained from 118 epileptic children (37 on carbamazepine, 47 on...

The skeleton plays a crucial role in human health. Comprehensive and non‐invasive visualization of the bone is high demand to detect bone‐related diseases. Clinically, traditional imaging methods still suffer from poor sensitivity, long capture time, inevitable ionizing radiation are inadequate for providing real‐time spatial information regarding cellular activity. Recently, various new techni...

Changes in osteoarthritis joint appear in the articular cartilage, synovium and in subchondral bone. It is necessary to find, apart from markers of cartilage destruction, a sensitive and specific biochemical marker which would reflect the metabolism as well as degradation of subchondral bone. Bone sialoprotein is mostly synthesized in osseous tissue found directly under the surface of joint car...

Biochemical markers of bone metabolism are divided into two groups: formation and resorption markers. Bone turnover is a dynamic process, which increases in postmenopausal period. Hormone replacement therapy (HRT) can diminish this increased bone turnover. Biochemical markers reflect acute changes in bone metabolism. Therefore, they may be very useful for the prediction of subsequent bone miner...

background: recently, osteoporosis is an increasingly important public health problem in men. the aim of this study was to investigate relationship between life style and bone mineral density in men. methods: among the 20-76 year-old men of tehran, 325 persons were selected randomly from 50 clusters. the persons suffering from rheumatoid arthritis, thyroid diseases, fractures or other condition...

PURPOSE The present review critically evaluates existing literature on the effects of short- and long-term low energy availability (EA) on bone metabolism and health in physically active individuals. METHODS We reviewed the literature on the short-term effects of low EA on markers of bone metabolism and the long-term effects of low EA on outcomes relating to bone health (bone mass, microarchi...