Patients with chronic kidney disease (CKD) have an increased risk of fracture. Raloxifene is a mild antiresorptive agent that reduces fracture risk in the general population. Here we assessed the impact of raloxifene on the skeletal properties of animals with progressive CKD. Male Cy/+ rats that develop autosomal dominant cystic kidney disease were treated with either vehicle or raloxifene for ...

The variability assessment of the rib bone mechanical properties during the growth process is still missing. These properties could not be obtained in vivo on children. Relationships have been obtained between Hounsfield Units from computed tomography (CT) and mechanical properties (e.g. for the cortical bone on adults). As a first step for investigation of the mechanical propertie...

Introduction Scaffolds fabricated from silk have shown good osteoinduction. However, the mechanical properties were insufficient to match native bone. We previously investigated the effects of mineral incorporation (by coating as well as embedding into the silk phase) as a method to enhance mechanical properties of porous silk scaffolds for bone tissue engineering. Based on encouraging results ...

Genistein, a major phytoestrogen of soy, is considered a potential drug for prevention and treatment of postmenopausal osteoporosis. The aim of the present study was to compare the effects of genistein, estradiol and raloxifene on the skeletal system in vivo and in vitro. Genistein (5 mg/kg), estradiol (0.1 mg/kg) or raloxifene hydrochloride (5 mg/kg) were administered daily by a stomach tube t...

The aim of this study was to explore the hierarchical arrangement of structural properties in cortical and trabecular bone and to determine a mathematical model that accurately predicts the tissue's mechanical properties as a function of these indices. By using a variety of analytical techniques, we were able to characterize the structural and compositional properties of cortical and trabecular...

Bone, at the ultra-structural level, is a composite with mechanical properties that can be matched by man-made composites. It serves as the template for developing bone replacement materials. Research on biomaterials analogous to bone was started in the early 1980s by incorporating bioactive particles into biocompatible polymers in order to produce bone substitutes. Hydroxyapatite reinforced hi...

the sustainability of the built environment is increasingly coming to the forefront of infrastructure design and maintenance decisions. to address this, development of a new class of more sustainable cement-based materials is needed. fiber reinforced self-consolidating mortar (frscm) was developed by optimizing the micromechanical parameters, which control composite properties in the hardened s...

linear low density polyethylene (lldpe) was blended with esterified styrene-maleic anhydride (esma) and its physical and mechanical properties were studied. styrene-maleic anhydride (sma) copolymer was synthesized by precipitation reaction. then, sma was esterified by 1-decanol in methylethyl ketone solvent. from the ftir spectrum of esma it is evident that the corresponding peaks of anhydride ...

a study has been made of the compaction properties of two experimental starches, namely yam starch obtained from dioscorea rotundata and rice starch obtained from oryza sativa and the mechanical properties of their tablets, in comparison with those of official corn starch. the influences of the physical and geometric properties of the starch particles on the compression properties of the starch...