BACKGROUND In order to achieve a safe and persistent angiogenic effect, we investigated the potential of bone marrow cells implantation to enhance angiogenesis of ischemic hearts in a rat model, and also we have investigated growth factors accompanying and intermediating the angiogenesis, and the changes occurring in the levels of cytokines and their relations with angiogenesis. METHODS 30 ad...

A 70-year-old female with a history of mild cirrhosis was referred by her primary care provider for a platelet count of 36,000/ μ L which had dropped from 47,000/ μ L in a week along with mild pain in extremities. Serum potassium was low (2.9 mEq/L) in spite of the patient being recently started on potassium supplement on outpatient for hypokalemia. Initially thrombocytopenia was attributed to ...

BACKGROUND Inflammatory cytokines in bone marrow may impair hematolymphopoiesis in human immunodeficiency virus (HIV)-infected subjects who do not experience reconstitution of CD4(+) T cells despite suppression of virus replication while receiving highly active antiretroviral therapy (HAART) (immunological nonresponders). METHODS Bone marrow samples from 12 immunological nonresponders receivi...

We determined the effects of yolk water-soluble protein (YSP) on bone resorption. YSP potently suppressed osteoclastogenesis from bone marrow-derived precursor cells driven by tumor necrosis factor-alpha (TNF-alpha). YSP (200 microg/ml) abolished the formation of tartarate-resistant acid phosphatase (TRAP)-positive osteoclasts. Furthermore, TNF-alpha induced TRAP activity was greatly inhibited ...

in order to study the normal hematopoiesis, cellular components and myeloid/erythroid (m/e) ratio in the bone marrow of the pheasant (phasianus colchicus), bone marrow samples were collected from the proximal tibiotarsus bone of 16 clinically healthy adult pheasant. the bone marrow smears were stained using the giemsa stain. the results indicated that the development and formation of blood cell...

Introduction: Hematopoiesis is an on going process mammalian marrow system. A few cells from the nucleated cells of bone marrow are hematopoietic cells which include primary stem cells, precursor cells and progenitor cells. Primary stem cells and progenitor cells are able to produce colonies in culture medium (CFU-C) and irradiated mouse spleen (CFU-S). A hematopoietic cell is alive and act...

Reaming of the long bones is widely practiced because it allows for improved healing and early mobilization in patients needing surgical debridement of bone tissue. The insertion of reamed intramedullary nails can cause complications such as bone necrosis, cortical blood supply damage, and fat or bone marrow embolism. We describe a novel way to limit the amount of material in the canal before n...

INTRODUCTION The risk of surgery-related infection is a persistent problem in orthopaedics and infections involving implants are particularly difficult to treat. This study explored the responses of bone and soft tissue to antimicrobial-coated screws. We investigated whether such screws, which have never been used to fix bony tissues, would result in a cytotoxic effect. We hypothesised that the...

Fas is type I membrane protein, expressed on various tissue including hematopoietic cell. Its ligand (FasL), a member of the tumor necrosis factor (TNF) family, which includes two forms of a membrane-bound form and a soluble one, induces apoptosis of Fas-bearing cells through cytotoxic activity. FasL is undetectable in the serum of healthy person, whereas it is high in that from patients with T...