Extraosseous accumulation of technetium-99m-methyl diphosphonate (99mTc-MDP) on bone scan is not common. This phenomenon is often attributed to abnormality of calcium metabolism and has been reported in a variety of conditions including metabolic diseases and malignancies. A five years old boy is presented here, who was admitted to the pediatric emergency suffering from fatigue, respiratory sym...

Neuroblastoma (NB), which arises from embryonic neural crest cells, is the most common extra-cranial solid tumor of childhood. Approximately half of NB patients manifest bone metastasis accompanied with bone pain, fractures and bone marrow failure, leading to disturbed quality of life and poor survival. To study the mechanism of bone metastasis of NB, we established an animal model in which int...

Timely detection of colorectal cancer metastases may permit improvements in their clinical management. Here, we investigated a putative role for bone marrow-derived cells in the induction of epithelial-to-mesenchymal transition (EMT) as a marker for onset of metastasis. In ectopic and orthotopic mouse models of colorectal cancer, bone marrow-derived CD11b(Itgam)(+)Jagged2 (Jag2)(+) cells infilt...

Increased chemotaxis toward activated serum was demonstrated by leukocytes from bone marrow, spleen, and peripheral blood of tumor-bearing mice as compared with those of normal mice. Increased chemotaxis was correlated with duration of tumor growth, which, in turn, was correlated with size of tumor. Upon surgical tumor removal, chemotaxis fell to normal levels unless metastasis had occurred, in...

Approximately 80% of prostate cancers exhibit some degree of bone metastasis. The role of the bone marrow and the hematopoietic stem cell (HSC) niche in attracting metastatic cells and maintaining dormancy of disseminated tumor cells (DTCs) is an increasingly important topic towards the development of novel prostate cancer therapies. This paper reviews aspects of the HSC niche that lead to pros...

objective(s) bone marrow is the traditional source of human multipotent mesenchymal stem cells (mscs), but adipose tissue appears to be an alternative and more readily available source. in this study, rat adipose-derived stem cells (adscs) were induced to differentiate into schwann-like cells and compared with rat bone marrow stem cells (bmscs) for their schwann-like cells differentiation poten...

introduction bacillus calmette-guérin (bcg) vaccine, a live attenuated mycobacterium bovis strain, is administrated to all newborn infants in endemic regions according to the current world health organization (who) recommendation. case presentation we report a 10-month-boy who was a known case of severe combined immunodeficiency (scid) admitted with multi-focal fusiform painful swelling in his ...

AIMS In vitro transfection experiments show that the nm23 gene suppresses metastasis, although the evidence from clinical studies is contradictory. The purpose of this study was to investigate whether nm23 selectively influences systemic, pleural, and lymphatic metastasis in non-small cell lung cancer (NSCLC). METHODS Forty two patients undergoing resection of NSCLC and lymph node sampling we...

Rectal carcinoids comprise 12.6% of all carcinoid tumors and represent the third largest group of the gut carcinoids. A 64-year-old woman was diagnosed as high-grade neuroendocrine carcinoma. She had liver, bone, and bone marrow metastasis. Carcinoid syndrome was diagnosed due to diarrhea, nausea, vomiting, tachycardia, and high level of 24-hour urinary 5-hydroxyindoleacetic acid (160 mg/24 hou...