Osteonecrosis (ON) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. Corticoid-induced ON in rats and lipopolysaccharide (LPS)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. D-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the ...

The bone marrow is one of the largest organs in the human body (Lund, 2000). It is the major hematopoietic organ and is important as both a primary and secondary lymphoid organ. Since it is a potential target organ of various disorders, evaluation of blood and bone marrow is an important component of any overall assessment studies. Bone marrow evaluation studies provide information about bone m...

Magnetic resonance imaging (MRI) is increasingly being used in the diagnostic work-up of patients with multiple myeloma. Since 2014, MRI findings are included in the new diagnostic criteria proposed by the International Myeloma Working Group. Patients with smouldering myeloma presenting with more than one unequivocal focal lesion in the bone marrow on MRI are considered having symptomatic myelo...

AIMS To measure Langerhans' cells in skin of patients treated by bone marrow transplantation who developed chronic graft versus host disease (GvHD); to determine whether the reduction in Langerhans' cells resulted directly from the GvHD or from other factors, such as the immunosuppressive regimens used in bone marrow transplant patients. PATIENTS AND METHODS Lesional and nonlesional skin spec...

objective(s) bone marrow is the traditional source of human multipotent mesenchymal stem cells (mscs), but adipose tissue appears to be an alternative and more readily available source. in this study, rat adipose-derived stem cells (adscs) were induced to differentiate into schwann-like cells and compared with rat bone marrow stem cells (bmscs) for their schwann-like cells differentiation poten...

adenocarcinoma of the stomach was the leading cause of cancer-related death worldwide through most of the 20th century. usual presentations of gastric cancer include anorexia, epigastric pain or discomfort and weakness. rarely, patients present with unusual clinical manifestations. in this article, we report two cases with uncommon presentations of gastric adenocarcinoma. the first patient was ...

introduction bacillus calmette-guérin (bcg) vaccine, a live attenuated mycobacterium bovis strain, is administrated to all newborn infants in endemic regions according to the current world health organization (who) recommendation. case presentation we report a 10-month-boy who was a known case of severe combined immunodeficiency (scid) admitted with multi-focal fusiform painful swelling in his ...

Previous studies showed that reconstitution of atherosclerosis-susceptible C57BL/6 (B6) female mice with apolipoprotein E (apoE)-deficient (apoE(-/-)) bone marrow resulted in markedly increased atherosclerosis, despite the fact that plasma lipid levels were unchanged. To determine whether apoE(-/-) bone marrow would increase atherosclerosis in an atherosclerosis-resistant strain, female C3H/HeJ...

T H E R E C O o N I T ! O N of ampicillin-resistant Hemophilus influenzae ~ has increased the use of chloramphenicol, particularly in management of invasive infections caused by this bacterium. Bone marrow toxicity, however, is a serious hazard. Based primarily on clinical data, two different bone marrow toxicities have been proposed. Reversible bone marrow suppression is frequent and dose rela...