Multipotent adult progenitor cells (MAPCs) are bone marrow-derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all 3 germinal layers: ectoderm, mesoderm, and endoderm. The origin of MAPCs within bone marrow is unknown. MAPCs are believed to be derived from the bone marrow stroma compartment as they are isolated withi...

background: in recent years, adipose tissue, due to the stem cells contained within, has found a new special place in laboratory and clinical applications. these adipose‑derived stem cells (adscs) have the same characteristics of bone marrow mesenchymal stem cells (bmscs). although bone marrow (bm) is not easily accessible and its procurements may be painful, most patients possess excess fat wh...

Cell therapy using stem cell transplantation against cerebral ischemia has been reported. However, it remains controversial regarding the optimal time for cell transplantation and the transplantation route. Rat models of cerebral ischemia were established by occlusion of the middle cerebral artery. At 1, 12 hours, 1, 3, 5 and 7 days after cerebral ischemia, bone marrow mesenchymal stem cells we...

Imbalance in immune responses plays an indispensable role pathogenesis and development of multiple sclerosis (MS), as a neurodegenerative disorder. Current treatments are not always successful preventing MS treating the disease. Stem cell-based cell therapy has provided new window for disorders. cells can regulate system improve axonal remyelination. They be isolated from different origins such...

Comment on: Jiang et al. Gene expression profiling suggests a pathological role of human bone marrow-derived mesenchymal stem cells in aging-related skeletal diseases. Aging 2011; this issue. In this issue of Impact Aging, Jiang et al. report key differences in the patterns of expressed mRNAs in bone-marrow mesenchymal stem cells (bmMSCs) of young donors compared with old human donors.

Neuroinflammation has a significant role in induce of Multiple sclerosis (MS) many approaches have been used to treat MS, but none of these methods have not been able to fully improve. One of the methods can suppress inflammation and regenerate the nervous system is the use of cell therapy. Using cell therapy in pre-clinic phase can be realized, it's mechanism and potency to suppress neuroinfla...

It is well accepted that umbilical cord blood has been a source for hematopoietic stem cells. However, controversy exists as to whether cord blood can serve as a source of mesenchymal stem cells, which can differentiate into cells of different connective tissue lineages such as bone, cartilage, and fat, and little success has been reported in the literature about the isolation of such cells fro...

neuroinflammation has a significant role in induce of multiple sclerosis (ms) many approaches have been used to treat ms, but none of these methods have not been able to fully improve. one of the methods can suppress inflammation and regenerate the nervous system is the use of cell therapy. using cell therapy in pre-clinic phase can be realized, it's mechanism and potency to suppress neuro...

In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...