Autophagy is a homeostatic process promoting cell survival in periods of stress. The induction of the autophagic machinery has also been implicated in both innate and adaptive immunity. Leishmania donovani, which is the causative pathogen of visceral leishmaniasis, is an intracellular parasite that invades and multiplies in bone marrow macrophages. We describe the induction of host cell autopha...

THE goal of tolerance induction, although achievable in pre-clinical models, is not yet a clinical reality. One of the most important areas of experimental research in thc field of tolerance induction has been the administration of donor-specific bone marrow in conjunction with whole organ transplantation. The same strategy has been tested in several clinical trials; all have included chronic i...

The transmission of a lymphomagenic agent(s) from the bone marrow of irradiated mice to thymic target cells has been demonstrated by: (a) the induction of T cell lymphomas in nonirradiated thymic grafts implanted in irradiated, Thy-l-congenic mice, (b) the induction of T cell lymphomas of host origin in mice infused with bone marrow from irradiated, Thy-l-congenic donors. The latter procedure a...

Bone marrow transfusion is a well-established method for induction of mixed hematopoietic chimerism and donor-specific tolerance in animal models. This procedure, however, is inapplicable in clinical transplantation using cadaveric donors due to the interval (1 week to 7 months) between tolerance induction and organ transplantation. For clinical use, it is essential that allografts be placed at...

many investigators use bone matrix gelatin for bone induction but it is used rarely for repair of teeth defects. this study was designed to evaluate secondary dentin formation by endochondral bone matrix gelatin (e-bmg) in rabbit. e-bmg was prepared from tibia and femur of 4 deutsche-poland rabbits with average ages of 4-6 months. the prepared e-bmg was implanted in right incisor teeth pulps of...

The sustained release of antibiotics from bone cement provides an opportunity for the induction of hypersensitivity. We evaluated the cellular and humoral immune responsiveness of guinea pigs to antibiotics diffusing from bone cement. We were unable to detect the presence of antibodies or skin hypersensitivity to any of the antibiotics tested.

A 16 year old boy presented soon after diagnosis of Crohn's disease with diffuse osteopenia of the lumbar spine with collapse of three vertebral bodies and grossly reduced bone mineral density noted on dual energy x ray absorptiometry scan. Treatment of the underlying Crohn's disease and induction of puberty resulted in marked improvement in bone mineralisation.