BACKGROUND In osteonecrosis the vascular supply of the bone is interrupted and the living cells die. The inorganic mineral network remains intact until ingrowing blood vessels invade the graft. Accompanying osteoclasts start to resorb the bone trabeculae and gradually replace the bone. If the osteonecrosis occurs in mechanically loaded parts, like in the subchondral bone of a loaded joint, the ...

Management of long bone defects occurring in accidents or war injuries is a difficult problem, From 1978 to 1986, 11 patients were treated for long bone defects of the humerus ( 10 cases) and radius (one case), using free vascularized fibular transfer by microsurgical technique .The patients were followed for 4 months and in all of them, selective angiography and scanning revealed exellent...

In this 2022 Update of Version 2020 the VI Consensus Brazilian Society Bone Marrow Transplantation (SBTMO) for Graft-versus-Host-Disease (GVHD), we seek to provide evidence-based guidance on all novel and clinically relevant advancements in both prophylaxis therapy Graft-versus-Host Disease those who delve into field Hematopoietic Stem Cell Transplantation.

The goals of surgery for spinal deformity are to correct or improve the deformity to get a stable, balanced and fused spine. The long-term success of any procedure for scoliosis depends on a solid arthrodesis. Getting fusion of the instrumented segment with the aid of copious autogenous iliac graft has been the most important goal of treatment. However, harvesting copious graft from teenage ili...

Autologous bone-patellar tendon-bone autograft is a common choice for anterior cruciate ligament reconstruction and from both biologic and biomechanical perspectives is well-suited for this purpose. A centrally harvested, 10 mm wide patellar tendon graft has an estimated initial load-to-failure of 2977 N, and interference screw fixation of associated bone blocks provides initial pull-out streng...

This study aimed to determine the guided bone regeneration (GBR) capacity of peri-implant bone defect treatment, either with only a hydroxyapatite bone graft or with a hydroxyapatite bone graft mixed with zoledronic acid (ZA) and employing polyethylene glycol (PEG) barrier membranes. In this study, four male New Zealand rabbits were used. First, the rabbits were randomly divided into two groups...

Synthetic bone graft substitutes have evolved in response to the downsides of autograft and allograft. This article consolidates the literature regarding the use of mineral bone graft substitutes in the treatment of cavitary bone defects. No level I studies regarding their use in the treatment of bone tumors have been performed, but the clinical studies that have been published indicate that ca...