We generated a new Bmp2 conditional-knockout allele without a neo cassette that removes the Bmp2 gene from osteoblasts (Bmp2-cKO(ob)) using the 3.6Col1a1-Cre transgenic model. Bones of Bmp2-cKO(ob) mice are thinner, with increased brittleness. Osteoblast activity is reduced as reflected in a reduced bone formation rate and failure to differentiate to a mature mineralizing stage. Bmp2 in osteobl...

Ten cases of post-traumatic recurrent dislocation of the peroneal tendons were operated on between 1974 and 1982. In all cases the disturbed superior peroneal retinaculum was reconstructed by transposition of the calcaneofibular ligament to the lateral side of the peroneal tendons. The calcaneal insertion of the calcaneofibular ligament was mobilised with a small bone block and reinserted in it...

Vertebral compression fractures are the most common fractures associated with osteoporosis. Approximately 700,000 osteoporosis-related vertebral compression fractures (OVCFs) occur each year in the U.S. Currently, treatment is focused primarily on prevention. When fractures occur in patients with osteoporosis, treatment options are limited to bed rest and pain medications because open surgery w...

A bone scan was done and the findings were consistent with a diagnosis of Paget's disease in the right femur. It also revealed small areas of activity in the skull and pelvis. There was no evidence of pathological fracture, sarcomatous degeneration, or metastasis from prostate. It was concluded that pain was due to an increase in activity of the Pagetic lesion in the femur. The patient was put ...

Rehabilitation as a process of return to fitness should take place at every stage the disease. Stimulation restore lost motor function all day, including when lying in bed or transferring from one position another. Placement items are an indispensable component restoring floatation, well element nursing patient. By correct arrangement patient we affect stimulatory nervous system. Thanks prevent...

In our previous study we used the linear-quadratic model [J. Nucl. Med. 35, 1861 (1994)] to confirm our initial finding, based on the time-dose-fractionation model [J. Nucl. Med. 34, 1801 (1993)], that longer-lived radionuclides (e.g., 32P, 91Y) can offer a substantial therapeutic advantage over the shorter-lived radionuclides presently used in radioimmunotherapy (e.g., 90Y). The original calcu...

The microgravity experienced during space flight induces physiological changes that affect astronauts' health and performance. Simulations such as prolonged bed rest can mimic some of these changes and provide study conditions that are more accessible than during space flight itself. Previous studies, including several long and short-term bed-rest campaigns supported by ESA, have yielded signif...

Aseptic loosening and periprosthetic osteolysis are major problems in artificial hip joint surgery,for which a solution has yet to be found. Biological host response to wear debris combined with cyclic mechanical loading onto the bone bed around hip prosthetic implants has been considered as mechanism responsible for implant-mediated periprosthetic osteolysis. Any type of artificial joint glidi...

The "screw shaped" expansion-condenser are hand instruments that were introduced for the first time at the end of the 70' in order to improve bone density before the positioning of a dental implant. Thanks to these hand instruments it is possibile to compact the bone apically and along the walls of the implant bed (Fig. 3) improving a lot the bone density and the primary stability of the implan...