Sustained stimulation of G-protein coupled receptors (GPCRs) leads to rapid loss of receptor function (acute desensitization). For many GPCRs including the mu-opioid receptor (MOR), an accepted mechanism for acute desensitization is through G-protein coupled receptor kinase (GRKs) mediated phosphorylation of the receptor, which facilitates the binding of beta-arrestins (betaarrs) to the recepto...

The primary molecular target for clinically used opioids is the μ-opioid receptor (MOR). Besides the major seven-transmembrane (7TM) receptors, the MOR gene codes for alternatively spliced six-transmembrane (6TM) isoforms, the biological and clinical significance of which remains unclear. Here, we show that the otherwise exclusively intracellular localized 6TM-MOR translocates to the plasma mem...

In this article we study the MOR cryptosystem. We use the group of unitriangular matrices over a finite field as the non-abelian group in the MOR cryptosystem. We show that a cryptosystem similar to the ElGamal cryptosystem over finite fields can be built using the proposed groups and a set of automorphisms of these groups. We also show that the security of this proposed MOR cryptosystem is equ...

In this paper we study the MOR cryptosystem. We use the group of unitriangular matrices over a finite field as the non-abelian group in the MOR cryptosystem. We show that a cryptosystem similar to the El-Gamal cryptosystem over finite fields can be built using the proposed groups and a set of automorphisms of these groups. We also show that the security of this proposed MOR cryptosystem is equi...

MicroRNA-offset RNAs (moRs) were first identified in simple chordates and subsequently in mouse and human cells by deep sequencing of short RNAs. MoRs are derived from sequences located immediately adjacent to microRNAs (miRs) in the primary miR (pri-miR). Currently moRs are considered to be simply a by-product of miR biosynthesis that lack biological activity. Here we show for the first time t...

The signaling molecule RGS9-2 is a potent modulator of G-protein-coupled receptor function in striatum. Our earlier work revealed a critical role for RGS9-2 in the actions of the μ-opioid receptor (MOR) agonist morphine. In this study, we demonstrate that RGS9-2 may act as a positive or negative modulator of MOR-mediated behavioral responses in mice depending on the agonist administered. Parall...

The septum initiation network (SIN) regulates multiple functions during late mitosis to ensure successful completion of cytokinesis in Schizosaccharomyces pombe. One mechanism by which the SIN promotes cytokinesis is by inhibiting a competing polarity pathway called the MOR, which is required for initiation of polarized growth following completion of cytokinesis. Mutual antagonism between the t...

Dopamine and opioid neurotransmitter systems share many functions such as regulation of reward and pleasure. μ-Opioid receptors (MOR) modulate the mesolimbic dopamine system in ventral tegmental area and striatum, key areas implicated in reward. We hypothesized that dopamine and opioid receptor availabilities correlate in vivo and that this correlation is altered in obesity, a disease with alte...

For the sake of improving product quality and economy, a series cold-pressing experiments were carried out to investigate material properties engineered wood flooring with emulsion polymer isocyanate adhesive. Effect pressing time, pressure, adhesive spreading rate on modulus elasticity (MOE) rupture (MOR) was analyzed based orthogonal experimental design. According results, both MOE MOR positi...