The stability of phosphoramide mustard, a metabolite of cyclophosphamide was studied at pH 7.2 and 37°Cusing 31Pnuclear magnetic resonance. The phosphorus signal of phosphoramide mustard disappeared with a half-life of 8 min indicating rapid conversion to other species. The final product, inorganic phos phate, appeared with a half-life of 105 min indicating that phos phoramide mustard was easi...

The presence of a quinone group in the structure of a series of model compounds was shown to produce cell kill by a mech anism involving free radicals and active oxygen species. Fur thermore, the ability of the compound to bind to DNA appeared to enhance its cytocidal activity. The same model compounds were used to investigate the effect of the quinone group on cellular DNA. DNA single-strand b...

Unambiguous and sensitive methods based on gas chromatography-chemical ionization mass spectrometry have been developed to quantitate Cyclophosphamide and two alkylating and cytotoxic metabolites, phosphoramide mustard and nornitrogen mustard. The levels of these materials have been determined in the plasma and urine of five patients receiving Cyclophosphamide, 60 or 75 mg/kg i.v. Peak plasma l...

purpose: to determine any possible correlation between delayed ocular complications with late-onset complications of mustard gas poisoning in other systems including skin, respiratory tract, and immunohematologic system. methods: the study was conducted on 40 chemical war victims in khorasan province, iran. ophthalmologic and dermatologic examinations and spirometry were performed for all patie...

Phytoextraction relies on plants with a high capacity to absorb heavy metals and remove them from the soil. The objective of this study was to analyze the potential of sunflower (Helianthus annuus L.) and white mustard (Sinapis alba L.) for phytoextraction of Zn-contaminated soil. Research was based on a strict pot experiment conducted in a greenhouse. Seven treatments were established with inc...

introduction: in comparison with rapeseed (canola), mustard has agronomic advantages such as drought tolerance and disease resistance, which empower this crop with a considerable oil production potential. mustard contains toxic substances e.g. glucosinolate, erucic acid, sinapine and tannin. the substances induce unpalatability, growth retardation, low feed efficiency, thyroid gland enlargement...

Abstract Background Mustard ( Brassica juncea ) is an important economic vegetable, and some cultivars have purple leaves accumulate more anthocyanins than the green. The genetic evolution of trait in mustard has not been well studied. Result In this study, free-hand sections metabolomics showed that accumulated green ones. gene controlling mustard, Purple Leaves MPL ), was genetically mapped a...