Implementing a suite of best management practices (BMPs) can reduce non-point source (NPS) pollutants from various land use activities. Watershed models are generally used to evaluate the effectiveness of BMP performance in improving water quality as the basis for watershed management recommendations. This study evaluates 171 management practice combinations that incorporate nutrient managemen...

We have investigated the role of FGFs in the control of programmed cell death during limb development by analyzing the effects of increasing and blocking FGF signaling in the avian limb bud. BMPs are currently considered as the signals responsible for cell death. Here we show that FGF signaling is also necessary for apoptosis and that the establishment of the areas of cell death is regulated by...

Despite improvements in implants and surgical techniques, osteoporotic fractures remain challenging to treat. Among other major risk factors, decreased expression of morphogenetic proteins has been identified for impaired fracture healing in osteoporosis. Bone grafts or bone graft substitutes are often used for stabilizing the implant and for providing a scaffold for ingrowth of new bone. Both ...

Irrigation and fertilization of crops are common practices necessary for the viability of agricultural communities, but also responsible for water scarcity and water quality deterioration. The effort to cost-effectively manage fresh water availability and diffuse nutrient pollution at the same time needs to take into account trade-offs between economic and multiple environmental objectives. Agr...

1798 Although water quality problems associated with agricultural nonpoint source (NPS) pollution have prompted the rapid and widespread adoption of a variety of so called “best management practices” (BMPs), there have been few realistic eff orts to assess their combined eff ectiveness in reducing NPS pollution. Th is study used the Variable Source Loading Function (VSLF) model, a distributed w...

Prevention and reduction of surface water pollution has been a matter of concern for decades, which has promoted the implementation of best management practices (BMPs) to ensure the protection of water resources. A considerable number of structural and non-structural BMPs have been developed to control hydrological processes and enhance pollutant load reduction at field and watershed scales. Ho...

Neural crest cells (NCCs) are pluripotent migratory cells that contribute to the development of various craniofacial structures. Many signaling molecules have been implicated in the formation, migration and differentiation of NCCs including bone morphogenetic proteins (BMPs). BMPs signal through a receptor complex composed of type I and type II receptors. Type I receptors (Alk2, Alk3 and Alk6) ...

Bone morphogenetic proteins (BMPs) are cytokines from the TGF-beta superfamily, with important roles during embryonic development and in the induction of bone and cartilage tissue differentiation in the adult body. In this contribution, we report the expression of recombinant human BMP-4, BMP-9, BMP-10, BMP-11 (or growth differentiation factor-11, GDF-11) and BMP-14 (GDF-5), using Escherichia c...

A Total Maximum Daily Load (TMDL) program has been initiated in the North Bosque River Watershed in Texas, USA, where point and nonpoint sources of pollution are of a concern. The Soil and Water Assessment Tool (SWAT), which had been validated for flow and sediment and nutrient transport, was applied to quantify the effects of Best Management Practices (BMPs) related to dairy manure management ...

Alterations in the signaling pathways of bone morphogenetic proteins (BMPs) and activation of the ERK/MAP kinase (MAPK) pathway by growth factors have been implicated in the development and progression of prostate cancer. Smad1 acts as a substrate for MAPKs and also performs a central role in transmitting signals from BMPs. We found that BMPs/Smad1 signaling inhibits the growth of androgen-sens...