نتایج جستجو برای: bmp

تعداد نتایج: 8738  

2007
Mihaela Serpe David Umulis Amy Ralston Jun Chen David J. Olson Hans Othmer Michael B. O’Connor Seth S. Blair

In Drosophila, the BMP binding protein Short gastrulation (Sog) both enhances and inhibits BMP activity in a spatially dependent manner, likely by facilitating transport of BMPs. In this report we examine the properties of a second Sog-like protein, Crossveinless 2 (Cv-2), and show that like Sog, it is a secreted BMP-binding protein that can either augment or inhibit BMP signaling. Unlike Sog h...

2014
Abigail Aleman Marlyn Rios Matthew Juarez Daniel Lee Annan Chen Edward Eivers

The BMP ligand Dpp, operates as a long range morphogen to control many important functions during Drosophila development from tissue patterning to growth. The BMP signal is transduced intracellularly via C-terminal phosphorylation of the BMP transcription factor Mad, which forms an activity gradient in developing embryonic tissues. Here we show that Cyclin dependent kinase 8 and Shaggy phosphor...

Journal: :Frontiers in bioscience : a journal and virtual library 2004
Di Chen Ming Zhao Stephen E Harris Zenghui Mi

Bone morphogenetic proteins (BMPs) are multi-functional growth factors and belong to the transforming growth factor beta (TGFbeta) superfamily. The roles of BMPs in embryonic development and cellular functions in postnatal animals have been extensively studied in recent years. Signal transduction studies have revealed that Smad1 and 5 are the immediate downstream molecules of BMP receptor and p...

Journal: :Journal of the Royal Society, Interface 2015
Tian Hong Ernest S Fung Lei Zhang Grace Huynh Edwin S Monuki Qing Nie

Temporal dynamics of morphogen-driven signalling events are critical for proper embryonic development. During development, cells translate extracellular bone morphogenetic protein (BMP) gradients, often subject to noise, into graded intracellular tail-phosphorylated SMAD (TP-SMAD) levels. Using modelling and experimental approaches, we found that BMPs induce TP-SMAD responses in neural precurso...

2012
Yi-Jyun Luo Yi-Hsien Su

Nodal and BMP signals are important for establishing left-right (LR) asymmetry in vertebrates. In sea urchins, Nodal signaling prevents the formation of the rudiment on the right side. However, the opposing pathway to Nodal signaling during LR axis establishment is not clear. Here, we revealed that BMP signaling is activated in the left coelomic pouch, specifically in the veg2 lineage, but not ...

2013
Zheng Guo Ian Driver Benjamin Ohlstein

Although much is known about injury-induced signals that increase rates of Drosophila melanogaster midgut intestinal stem cell (ISC) proliferation, it is largely unknown how ISC activity returns to quiescence after injury. In this paper, we show that the bone morphogenetic protein (BMP) signaling pathway has dual functions during midgut homeostasis. Constitutive BMP signaling pathway activation...

2016
Jin-Chul Park Eun-Bin Bae Se-Eun Kim So-Yun Kim Kyung-Hee Choi Jae-Won Choi Ji-Hyeon Bae Jae-Jun Ryu Jung-Bo Huh

This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as di...

Journal: :Food and Bioprocess Technology 2022

The impacts of four treatments, ultra-high hydrostatic pressure (UHP), high-pressure homogenization (HPH), combined UHP + HPH (U-H), and (H-U), on bighead carp (Aristichthys nobilis) myofibrillar protein (BMP) structure, functional hydrolysis property to pepsin, antioxidant activity hydrolysates were investigated. All treatments led increase in low-molecular-weight BMP, the BMP stability, hydro...

Journal: :Genetics and molecular research : GMR 2012
S H Yuan C B Gao C U Yin Z G Yin

The biological effects of transfection of an adeno-associated virus (AAV) vector with bone morphogenetic proteins 4 and 7 (BMP-4/7) fusion gene (AAV-BMP-4/7) were determined in rabbit bone marrow stromal cells (BMSCs). BMP-4 and BMP-7 genes were obtained through one-step reverse transcriptase polymerase chain reaction from human placental cells. The BMP-4/7 fusion gene was then generated ...

Journal: :Arthritis Research & Therapy 2008
Masaya Hayashi Takeshi Muneta Young-Jin Ju Tomoyuki Mochizuki Ichiro Sekiya

INTRODUCTION We investigated the ability of a weekly intra-articular injection of bone morphogenetic protein (BMP)-7 to prevent osteoarthritis in rabbits with anterior cruciate ligament transections. METHODS First, 36 knee joints were randomly divided into four groups: 50, 500, 5,000 ng BMP-7, and control. Knee cartilage was evaluated at 4, 8, and 12 weeks. Then, in order to control for indiv...

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